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Ketogenic Diet and Drug-Induced Hepatotoxicity During Tuberculosis Treatment
Francisco Branco Caetano1, Tiago Milheiro Silva1, Cristina Gonçalves2
1From the Infectious Diseases Unit, Pediatric Department, Hospital Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.
Abstract:
When therapy with hepatotoxic drugs is being considered, all other possible contributing agents of liver damage should be held to account. While not generally considered a risk factor, we present 2 cases in which ketogenic diet (KD) may have played a role in liver injury due to antituberculosis drugs. Ketogenic diet has been linked to liver injury, and while its pathophysiology remains obscure, carnitine depletion could play a role, as it is a mechanism of liver damage common to KD and antituberculosis drug regimens.
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