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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
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Therapeutic hypothermia can cause non-infective C-reactive protein elevating
Xiaohong Wang1, Liping Shi1, Chenhong Wang1
1Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Frontiers in Pediatrics
|May 11, 2023
Summary
Therapeutic hypothermia (TH) may increase high-sensitivity C-reactive protein (hs-CRP) levels in neonates with hypoxic-ischemic encephalopathy (HIE). Higher HIE severity correlates with increased hs-CRP elevation risk, suggesting it is unrelated to infection.
Area of Science:
- Neonatal Medicine
- Pediatric Neurology
- Biochemistry
Background:
- Hypoxic-ischemic encephalopathy (HIE) is a serious condition in newborns.
- Therapeutic hypothermia (TH) is a standard treatment for HIE.
- High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation.
Purpose of the Study:
- To investigate the relationship between TH and hs-CRP levels in neonates with HIE.
- To determine if TH influences hs-CRP elevation timing and magnitude.
- To correlate hs-CRP changes with HIE severity and potential infection.
Main Methods:
- Retrospective analysis of 83 neonates with HIE treated between January 2014 and June 2021.
- Comparison of hs-CRP, WBC, neutrophil percentage, and PLT between TH and control groups.
- Correlation analysis of hs-CRP elevation with brain MRI findings and HIE severity.
Main Results:
- Elevated hs-CRP was significantly higher in the TH group (60.0%) compared to the control group (7.1%).
- hs-CRP elevation occurred 72-96 hours post-TH and correlated with HIE severity.
- TH showed a trend towards decreasing PLT and WBC, but without statistical significance.
Conclusions:
- TH can increase hs-CRP levels in HIE neonates, with higher risk in severe HIE.
- hs-CRP elevation post-TH is likely not due to infection, reducing the need for active antibiotic use.
- The findings suggest monitoring hs-CRP in HIE neonates undergoing TH, considering HIE severity.
Keywords:
brian injuryc-Reactive proteinhypoxic-ischemic encephalopathy (HIE)neonataltherapeutic hypothermia(TH)More Related Videos
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