Swarming self-adhesive microgels enabled aneurysm on-demand embolization in physiological blood flow

Area of Science:

• Biomedical Engineering
• Robotics
• Materials Science

Background:

• Minimally invasive embolization for aneurysms faces challenges in microrobot delivery and precise control.
• Existing methods struggle with targeted delivery and consistent filling within the aneurysm sac.

Purpose of the Study:

• To develop an interventional catheterization-integrated swarming microrobotic platform for on-demand aneurysm embolization.
• To address limitations in delivery capability and filling controllability for microrobot-based aneurysm treatments.

Main Methods:

• Developed pH-responsive, self-healing hydrogel microgels with magnetic and imaging agents for controlled adhesion.
• Utilized catheter-assisted deployment and external magnetic fields for targeted microgel aggregation within the aneurysm.
• Employed real-time ultrasound and fluoroscopy for precise guidance and monitoring during the procedure.

Main Results:

• Achieved on-demand embolization of aneurysms in physiological blood flow using the developed microrobotic platform.
• Demonstrated long-term self-adhesion of microgels under biological conditions via pH-triggered welding.
• Confirmed satisfactory biocompatibility and hemocompatibility, along with physical stability of the embolized region.

Conclusions:

• The developed swarming microrobotic platform offers a promising solution for targeted aneurysm embolization.
• This approach enhances controllability and delivery capabilities for microrobotic interventions in dynamic physiological environments.
• The study highlights the potential of integrating microrobotic swarm design and control for practical medical applications.