Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Enteric Nervous System: Regulation of GI Motor Activity

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...

Nerve Supply of the GI Tract

Nerve Supply of the GI Tract

The neuronal supply to the gastrointestinal (GI) tract is essential for regulating various functions, including digestion, absorption, and movement of food. This intricate network of nerves is known as the enteric nervous system (ENS), often referred to as the "second brain" of the body.
The enteric nervous system consists of two major plexuses: the myenteric plexus (Auerbach's plexus) and the submucosal plexus (Meissner's plexus). These plexuses are located within the layers of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nocturnal salivary cortisol and perceived stress in schoolteachers: a pilot study.

Frontiers in psychiatry·2026

Same author

Distinct Swimming Behavioral Phenotypes Following Serotonin and Dopamine Transporter Modulation in the Adult Zebrafish Novel Tank Diving Test (NTT).

Pharmaceuticals (Basel, Switzerland)·2025

Same author

Juvenile Rats Exposed to Antibiotics Early in Life Display Sexual Dimorphisms on Social Behaviour and Sex Hormone Deconjugating Activity.

Journal of neurochemistry·2025

Same author

Beta 3-adrenoceptor agonism ameliorates early-life stress-induced visceral hypersensitivity in male rats.

Journal of neurochemistry·2023

Same author

Early-Life Exposure to Non-Absorbable Broad-Spectrum Antibiotics Affects the Dopamine Mesocorticolimbic Pathway of Adult Rats in a Sex-Dependent Manner.

Frontiers in pharmacology·2022

Same author

Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation.

International journal of molecular sciences·2021

Search research articles

Related Experiment Video

Updated: Jul 30, 2025

In Situ Ca2+ Imaging of the Enteric Nervous System

In Situ Ca2+ Imaging of the Enteric Nervous System

Published on: January 29, 2015

Mapping and quantifying neuropeptides in the enteric nervous system.

Alex González-Vergara¹, Benjamín Benavides¹, Marcela Julio-Pieper¹

¹Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.

Journal of Neuroscience Methods

|May 12, 2023

Summary

Neuropeptides, crucial signaling molecules in the nervous system, present analytical challenges, especially in the enteric nervous system (ENS). Further technical development is needed to understand their roles in health and disease.

Keywords:

Enteric nervous system Myenteric plexus Neuropeptides Submucosal plexus

More Related Videos

Immunostaining to Visualize Murine Enteric Nervous System Development

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

Related Experiment Videos

Last Updated: Jul 30, 2025

In Situ Ca2+ Imaging of the Enteric Nervous System

In Situ Ca2+ Imaging of the Enteric Nervous System

Published on: January 29, 2015

Immunostaining to Visualize Murine Enteric Nervous System Development

Immunostaining to Visualize Murine Enteric Nervous System Development

Published on: April 29, 2015

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

A Quantitative Cell Migration Assay for Murine Enteric Neural Progenitors

Published on: September 18, 2013

Area of Science:

Neuroscience
Molecular Biology
Gastroenterology

Background:

Neuropeptides are diverse signaling molecules in the central nervous system (CNS) and peripheral organs like the enteric nervous system (ENS).
Research increasingly explores neuropeptide roles in neural and non-neural diseases and their therapeutic potential.
Understanding neuropeptide production and functions is vital for biological process comprehension.

Purpose of the Study:

To review the analytical challenges in neuropeptide research, with a specific focus on the ENS.
To highlight opportunities for advancing neuropeptide detection and analysis techniques.

Main Methods:

Literature review of neuropeptide research methodologies.
Analysis of challenges in detecting low-abundance neuropeptides in complex tissues like the ENS.
Identification of current and emerging analytical techniques.

Main Results:

Neuropeptide analysis faces significant hurdles, particularly in the ENS due to low concentrations.
Existing analytical methods may require optimization for comprehensive neuropeptide profiling.
Technological advancements are crucial for overcoming these limitations.

Conclusions:

Addressing analytical challenges is key to fully elucidating neuropeptide functions in health and disease.
Further development of sensitive and specific analytical techniques is imperative for neuropeptide research.
Enhanced understanding of neuropeptides will impact neuroscience and related fields.