Related Experiment Video
Updated: Jul 30, 2025
04:33
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
697
CT airway remodelling and chronic cough
Hazim Abozid1,2, Miranda Kirby3,4, Neha Nasir3
1Department of Respiratory and Pulmonary Diseases, Clinic Penzing, Vienna, Austria hazim@live.at.
BMJ Open Respiratory Research
|May 12, 2023
Summary
Chronic cough (CC) is not linked to specific airway structural changes on CT scans. However, CC is independently associated with a faster decline in lung function (FEV1), especially in ever-smokers.
Area of Science:
- Pulmonary Medicine
- Radiology
- Respiratory Health
Background:
- Structural airway changes are linked to chronic cough (CC), but data are limited and inconclusive.
- Advanced CT imaging can quantify airway abnormalities and count visible airways.
Purpose of the Study:
- To evaluate airway abnormalities in CC using CT imaging.
- To assess the contribution of CC and CT findings to airflow limitation progression (FEV1 decline).
Main Methods:
- Analysis of thoracic CT scans and spirometry from 1183 participants (aged ≥40 years) from the Canadian Obstructive Lung Disease study.
- Participants stratified into never-smokers, ever-smokers with normal lung function, and COPD patients.
- Imaging parameters included total airway count (TAC), airway wall thickness, emphysema, and small airway disease quantification.
Main Results:
- CC was not associated with specific airway or lung structural features, regardless of COPD presence.
- CC was significantly associated with FEV1 decline over time in the entire cohort, particularly in ever-smokers (p<0.0001).
- This association remained independent of TAC and emphysema score.
Conclusions:
- The lack of specific CT structural features suggests other mechanisms underlie CC symptomatology.
- CC is independently associated with FEV1 decline, beyond CT-derived parameters.
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