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Renal function and lithium: a longitudinal study.

J R DePaulo, E I Correa, D G Sapir

    The American Journal of Psychiatry
    |July 1, 1986
    PubMed
    Summary
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    Lithium treatment for bipolar disorder generally shows minimal kidney function changes. While some patients experience increased urine volume, most maintain stable renal function over time.

    Area of Science:

    • Nephrology
    • Psychiatry
    • Pharmacology

    Background:

    • Lithium is a cornerstone treatment for bipolar disorder.
    • Long-term lithium therapy can affect renal function.
    • Understanding the progression of renal changes is crucial for patient management.

    Purpose of the Study:

    • To assess the longitudinal changes in renal function in patients treated with lithium.
    • To determine the prevalence and degree of renal impairment associated with lithium therapy.
    • To correlate renal function changes with serum lithium levels.

    Main Methods:

    • Longitudinal study design.
    • Inclusion of 40 patients with bipolar disorder on lithium therapy.
    • Two renal function assessments conducted 6 to 18 months apart.

    Related Experiment Videos

  • Glomerular filtration rate and 24-hour urine volume measurements.

    • Main Results:

    • No significant change in glomerular filtration rate observed.
    • Average 24-hour urine volume increased significantly, but with considerable inter-patient variability.
    • Most patients exhibited minimal or no substantial change in urine volume.
    • A small subset of patients showed marked increases in urine volume (polyuria).
    • Renal function changes correlated with serum lithium levels.

    Conclusions:

    • The majority of lithium-treated patients experience little renal concentrating impairment.
    • A small proportion of patients may develop significant polyuria with continued lithium treatment.
    • Monitoring renal function, particularly urine volume, is important in long-term lithium therapy.