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Related Concept Videos

Insomnia01:27

Insomnia

111
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
111
Management of Insomnia01:19

Management of Insomnia

289
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
289
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

206
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
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Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

187
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
187
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

201
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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Updated: Jul 30, 2025

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
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Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

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Do Insomnia Treatments Improve Daytime Function?

Nathaniel F Watson1, Suzanne M Bertisch2, Charles M Morin3

  • 1Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA.

Journal of Clinical Medicine
|May 13, 2023
PubMed
Summary
This summary is machine-generated.

Expert sleep specialists found that insomnia treatments do not uniformly improve daytime impairment, contrary to common medical opinion. This highlights a gap in understanding insomnia treatment efficacy.

Keywords:
clinical appraisaldaytime functioninsomniamedications

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Area of Science:

  • Sleep Medicine
  • Clinical Research
  • Evidence-Based Practice

Background:

  • Insomnia is a prevalent sleep disorder associated with significant daytime impairment.
  • General medical opinion suggests insomnia treatments uniformly improve daytime functioning.
  • A discrepancy may exist between clinical practice and scientific evidence regarding treatment efficacy.

Purpose of the Study:

  • To clinically appraise the statement: 'Treatments for insomnia have uniformly been shown to significantly improve the associated daytime impairment seen with insomnia.'
  • To compare general medical opinion on insomnia treatment with the available scientific evidence.
  • To identify gaps between published evidence and practicing clinicians' beliefs.

Main Methods:

  • A scientific advisory panel of seven U.S. and Canadian sleep experts convened.
  • The panel conducted a clinical appraisal by comparing survey data of practicing clinicians' opinions with published medical literature.
  • Evidence from the published medical literature was reviewed and discussed.

Main Results:

  • The expert advisory panel concluded that the medical literature does not support the statement that insomnia treatments uniformly improve daytime impairment.
  • A national survey of primary care physicians, psychiatrists, nurse practitioners, physician assistants, and sleep specialists revealed a general medical opinion that contrasts with the scientific evidence.
  • Discrepancies were identified between the evidence base and general medical opinion.

Conclusions:

  • The available scientific evidence does not support the notion that all insomnia treatments uniformly improve daytime impairment.
  • General medical opinion regarding the efficacy of insomnia treatments in improving daytime impairment is not fully aligned with the scientific literature.
  • There is a need to educate the general medical community to improve insomnia treatment outcomes.