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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Obesity, Preserved Ejection Fraction Heart Failure, and Left Ventricular Remodeling
Jason Stencel1, Hamid R Alai1,2, Aneesh Dhore-Patil1
1Section of Cardiology, John W. Deming Department of Medicine, Tulane University School of Medicine, Tulane University Heart and Vascular Institute, New Orleans, LA 70112, USA.
Journal of Clinical Medicine
|May 13, 2023
Summary
Severe obesity often leads to heart failure with preserved ejection fraction (HFpEF). This study explores if significant weight loss through bariatric surgery can reverse cardiac changes in obese patients with HFpEF.
Area of Science:
- Cardiology
- Metabolic Disorders
- Obesity Medicine
Background:
- The global obesity epidemic is increasing the prevalence of heart failure with preserved ejection fraction (HFpEF).
- Obesity and HFpEF share common cardiovascular, immune, and renal dysfunctions.
- It remains unclear if HFpEF in obesity is a convergence of two conditions or if obesity drives HFpEF development.
Purpose of the Study:
- To investigate the impact of substantial weight loss on cardiac remodeling in severe obesity.
- To determine if metabolic bariatric surgery can reverse left ventricular abnormalities in obese patients with HFpEF.
Main Methods:
- Observational study design.
- Assessment of cardiovascular parameters before and after metabolic bariatric surgery.
- Evaluation of left ventricular remodeling in patients with obesity and HFpEF.
Main Results:
- Patients with severe obesity frequently develop HFpEF, characterized by concentric left ventricular remodeling.
- Metabolic bariatric surgery leads to significant and sustained excess body weight loss.
- Further research is needed to confirm the reversal of cardiac remodeling post-surgery.
Conclusions:
- The obese phenotype of HFpEF presents a unique model to study the effects of weight loss on cardiac structure.
- Metabolic bariatric surgery offers a potential therapeutic strategy for reversing cardiac remodeling in obese HFpEF patients.
- Understanding the interplay between obesity and HFpEF is crucial for effective clinical management.
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