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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

335
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
335
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

240
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
240
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

159
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
159
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

655
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
655
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

351
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
351

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Chitosan-Based Polymer Blends for Drug Delivery Systems.

Malkiet Kaur1, Ameya Sharma2, Vivek Puri2

  • 1Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.

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|May 13, 2023
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Chitosan blends enhance polymer properties for advanced drug delivery. These novel nanocarriers offer controlled, cost-effective, and sustained release of therapeutics, improving drug safety and efficacy.

Keywords:
biopolymerschitosandrug deliverynanocarrierspolymer blends

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Pharmaceutical Sciences

Background:

  • Polymers are crucial for controlled drug delivery, enabling consistent dosing and adjustable release of various drugs.
  • Polymer blends offer superior performance over homopolymers in drug development.
  • Chitosan, a versatile biopolymer, is being explored in blends to improve its inherent properties for drug delivery applications.

Purpose of the Study:

  • To review recent research on chitosan blends for enhanced drug delivery systems.
  • To explore the diverse applications of chitosan blends in pharmaceutical formulations.
  • To highlight the advantages of chitosan-based nanocarriers in therapeutic delivery.

Main Methods:

  • Literature review of research published in the past ten years.
  • Data compilation from scientific databases (ScienceDirect, J-Gate, Google Scholar, PubMed).
  • Analysis of novel nanocarrier systems utilizing chitosan blends.

Main Results:

  • Chitosan blends demonstrate improved properties compared to pure chitosan.
  • Nanocarriers derived from chitosan blends exhibit a positive surface charge, enabling controlled drug release kinetics.
  • These advanced systems facilitate controlled rate, duration, and site-specific drug delivery.

Conclusions:

  • Chitosan blends represent a promising strategy for developing advanced drug delivery systems.
  • Chitosan-based nanocarriers offer enhanced safety, efficacy, and prolonged drug release.
  • The cost-effectiveness and versatility of chitosan blends make them suitable for various dosage forms.