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Updated: Jul 30, 2025

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
Published on: February 24, 2021
UWB-Modulated Microwave Imaging for Human Brain Functional Monitoring
Youness Akazzim1,2, Marc Jofre1,3, Otman El Mrabet2
1School of Telecommunication Engineering, Universitat Politècnica de Catalunya, 08034 Barcelona, Spain.
Abstract:
Morphological microwave imaging has shown interesting results on reconstructing biological objects inside the human body, and these parameters represent their actual biological condition, but not their biological activity. In this paper, we propose a novel microwave technique to locate the low-frequency (f≃1 kHz) -modulated signals produced by a microtag mimicking an action potential and proved it in a cylindrical phantom of the brain region. A set of two combined UWB microwave applicators, operating in the 0.5 to 2.5 GHz frequency band and producing a nsec interrogation pulse, is able to focus its radiated field into a small region of the brain containing the microtag with a modulated photodiode. The illuminating UWB microwave field was first modulated by the low-frequency (f≃1 kHz) electrical signal produced by the photodiode, inducing modulated microwave currents into the microtag that reradiating back towards the focusing applicators. At the receiving end, the low-frequency (f≃1 kHz) -modulated signal was first extracted from the full set of the backscattered signals, then focused into the region of interest and spatially represented in the corresponding region of the brain, resulting in a spatial resolution of the images in the order of 10 mm.

