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Published on: June 20, 2025
Development of stem cell therapy for atherosclerosis
Yun Ma1,2,3, Tianhe Gu1, Siqi He1
1Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, 421001, Hunan, China.
Insights
Stem cell therapy, particularly using mesenchymal stem cells (MSCs), shows promise for treating atherosclerosis (AS), a major cause of cardiovascular disease (CVD). Research explores MSCs and exosomes for new therapeutic strategies beyond statins.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Cellular Therapy
Background:
- Atherosclerosis (AS) is a primary contributor to cardiovascular disease (CVD), characterized by lipid deposition.
- Current treatments like statins have limited efficacy in curing AS.
- There is a critical need for novel therapeutic approaches to manage AS.
Purpose of the Study:
- To review recent advancements in stem cell therapy for AS.
- To summarize factors contributing to AS formation.
- To evaluate the potential of mesenchymal stem cells (MSCs) and exosomes in AS treatment.
Main Methods:
- Focus on stem cell therapy, specifically mesenchymal stem cells (MSCs).
- Review of current research on stem cell technology and cellular therapies for AS.
- Exploration of the role and potential of exosomes in AS treatment.
Main Results:
- Stem cell transplantation has demonstrated efficacy in various diseases.
- Mesenchymal stem cells (MSCs) show significant potential for AS treatment.
- Exosomes present a promising avenue for AS therapeutic strategies.
Conclusions:
- Stem cell-based therapies offer new hope for treating atherosclerosis.
- Mesenchymal stem cells (MSCs) and exosomes are key areas for future AS therapeutic development.
- Further research is needed to translate these findings into clinical applications for cardiovascular disease.
Abstract:
Cardiovascular disease (CVD) has a high incidence and low cure rate worldwide, and atherosclerosis (AS) is the main factor inducing cardiovascular disease, of which lipid deposition in the vessel wall is the main marker of AS. Currently, although statins can be used to lower lipids and low-density lipoprotein (LDL) in AS, the cure rate for AS remains low. Therefore, there is an urgent need to develop new therapeutic approaches, and stem cells are now widely studied, while stem cells are a class of cell types that always maintain the ability to differentiate and can differentiate to form other cells and tissues, and stem cell transplantation techniques have shown efficacy in the treatment of other diseases. With the establishment of cellular therapies and continued research in stem cell technology, stem cells are also being used to address the problem of AS. In this paper, we focus on recent research advances in stem cell therapy for AS and briefly summarize the relevant factors that induce the formation of AS. We mainly discuss the efficacy and application prospects of mesenchymal stem cells (MSCs) for the treatment of AS, in addition to the partial role and potential of exosomes in the treatment of AS. Further, provide new ideas for the clinical application of stem cells.
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