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Selenium, alcohol and liver diseases.

J Aaseth, A Smith-Kielland, Y Thomassen

    Annals of Clinical Research
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Selenium and zinc levels are decreased in alcoholic cirrhosis patients. This deficiency may increase liver vulnerability to ethanol toxicity, suggesting potential therapeutic benefits of supplementation.

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    Area of Science:

    • Hepatology
    • Nutritional Biochemistry

    Background:

    • Alcoholic cirrhosis is a significant health concern.
    • Previous research suggests a link between selenium deficiency and liver disease.
    • Ethanol consumption is known to affect liver cell function and antioxidant levels.

    Purpose of the Study:

    • To investigate serum concentrations of selenium, copper, and zinc in patients with alcoholic cirrhosis.
    • To compare these levels with those in patients suffering from chronic active hepatitis and primary biliary cirrhosis.
    • To explore the potential pathogenetic role of selenium and zinc deficiencies in alcoholic liver disease.

    Main Methods:

    • Serum samples were collected from patients diagnosed with alcoholic cirrhosis, chronic active hepatitis, and primary biliary cirrhosis.

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  • Concentrations of selenium, copper, and zinc were measured in these serum samples.
  • Data analysis focused on comparing mineral levels across different liver disease groups.

    • Main Results:

    • Serum selenium concentrations were consistently lower in patients with alcoholic cirrhosis.
    • Zinc levels were also found to be decreased in patients with alcoholic cirrhosis.
    • These findings suggest a specific pattern of mineral deficiency in alcoholic liver disease.

    Conclusions:

    • Selenium and zinc deficiencies are prevalent in alcoholic cirrhosis.
    • Low selenium and zinc levels, potentially combined with glutathione depletion, may render hepatocytes more susceptible to ethanol-induced toxicity.
    • Further research into zinc and selenium supplementation as a therapeutic strategy for alcoholic cirrhosis is warranted.