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Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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Wound infections associated with absorbable or metallic devices used in the fixation of fractures, arthrodeses and osteotomies.

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Related Experiment Video

Updated: Jun 22, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 10, 2011

Multiresistant Staphylococcus epidermidis as a pathogen.

L Heikkonen, A Palmu, O Böstman

    Annals of Clinical Research
    |January 1, 1986
    PubMed
    Summary

    Multiresistant Staphylococcus epidermidis (MSE) strains are common in hospitals, causing significant infections like wound and urinary tract infections. Over half of all Staphylococcus epidermidis strains isolated were multiresistant.

    Area of Science:

    • Microbiology
    • Clinical Medicine
    • Infectious Diseases

    Background:

    • Staphylococcus epidermidis is a common cause of hospital-acquired infections.
    • The increasing prevalence of antimicrobial resistance poses a significant threat to patient care.

    Purpose of the Study:

    • To investigate the occurrence and clinical significance of multiresistant Staphylococcus epidermidis (MSE) strains.
    • To determine the role of MSE as a pathogen in various hospital departments.

    Main Methods:

    • Prospective study of 178 in-patients from whom MSE was isolated over six months.
    • Definition of multiresistant strains as those resistant to ≥3 antimicrobial agents.
    • Daily monitoring of patients for signs of infection and identification of the causative pathogen.

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    Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
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    Published on: February 14, 2025

    Main Results:

    • Multiresistant Staphylococcus epidermidis accounted for 57.9% of all isolated Staphylococcus epidermidis strains.
    • Clinical infection occurred in 155 patients; MSE was the likely pathogen in 115 (65%).
    • Common infections included wound infections (43%) and urinary tract infections (37%).

    Conclusions:

    • Multiresistant Staphylococcus epidermidis is a prevalent pathogen in university hospital settings.
    • MSE is frequently implicated in significant nosocomial infections, particularly wound and urinary tract infections.
    • Effective antimicrobial stewardship is crucial to manage infections caused by MSE.