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Updated: Jun 22, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 10, 2011
Multiresistant Staphylococcus epidermidis as a pathogen
Abstract:
The purpose of this study was to examine the occurrence and the present clinical significance of multiresistant strains of Staphylococcus epidermidis (MSE) at the departments of internal medicine, general surgery, neurology and lung diseases of an university hospital. All those 178 consecutive in-patients from whom, during a half-year investigation period, a strain of MSE was isolated, were immediately enrolled in the study. A strain was defined as multiresistant if it was resistant to 3 or more antimicrobial agents. The clinical course of the patients was followed prospectively daily for any sign of infection. The multiresistant strains amounted to 57.9% of all recovered Staph. epidermidis strains. The mean age of the patients was 50.3 years. A chronic underlying disease was present in 97%. There was a clinical infection in 155 patients, and in 115 of these (65% of the total) the MSE very probably was the true pathogen. The distribution of these infections was as follows: wound infection in 49 (43%), urinary tract infection in 43 (37%), local soft tissue infection in 13 (11%) and septicaemia in 10 (9%) patients. In 40 patients (22% of the total) the role of the MSE in the infection remained uncertain and in 23 patients (13%) the finding obviously was an accidental skin contamination.
Insights
Multiresistant Staphylococcus epidermidis (MSE) strains are common in hospitals, causing significant infections like wound and urinary tract infections. Over half of all Staphylococcus epidermidis strains isolated were multiresistant.
Area of Science:
- Microbiology
- Clinical Medicine
- Infectious Diseases
Background:
- Staphylococcus epidermidis is a common cause of hospital-acquired infections.
- The increasing prevalence of antimicrobial resistance poses a significant threat to patient care.
Purpose of the Study:
- To investigate the occurrence and clinical significance of multiresistant Staphylococcus epidermidis (MSE) strains.
- To determine the role of MSE as a pathogen in various hospital departments.
Main Methods:
- Prospective study of 178 in-patients from whom MSE was isolated over six months.
- Definition of multiresistant strains as those resistant to ≥3 antimicrobial agents.
- Daily monitoring of patients for signs of infection and identification of the causative pathogen.
Main Results:
- Multiresistant Staphylococcus epidermidis accounted for 57.9% of all isolated Staphylococcus epidermidis strains.
- Clinical infection occurred in 155 patients; MSE was the likely pathogen in 115 (65%).
- Common infections included wound infections (43%) and urinary tract infections (37%).
Conclusions:
- Multiresistant Staphylococcus epidermidis is a prevalent pathogen in university hospital settings.
- MSE is frequently implicated in significant nosocomial infections, particularly wound and urinary tract infections.
- Effective antimicrobial stewardship is crucial to manage infections caused by MSE.
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