Related Experiment Video
Updated: Oct 2, 2026

High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
Published on: November 16, 2016
[Effect of chloramphenicol on the toxic and therapeutic actions of cyclophosphane]
Abstract:
The effect of chloramphenicol on the toxic and therapeutic action of cyclophosphamide was studied on CBA and DBA male mice. The animals were intact or infected with L1210 leukemia. It was found that the use of chloramphenicol prolonged the life-span of the mice and/or increased the number of the survivals after exposure to the lethal doses of cyclophosphamide. It reduced leukopenia and almost completely protected the animals from macular canities developing after administration of cyclophosphamide. The therapeutic effect of cyclophosphamide did not change after the use of chloramphenicol. The mechanisms of the above diverse effects of chloramphenicol on the toxic and therapeutic action of cyclophosphamide and the possibility of the use of chloramphenicol for lowering the cyclophosphamide toxicity in treatment of oncological patients are discussed.
More Related Videos
07:28Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Published on: October 29, 2020
10:24A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Related Concept Videos
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Pharmacokinetics: Drug–Drug Interactions
Drug Toxicity: Dose-Dependent Reactions
Inhibitors of Bacterial Protein Synthesis