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Updated: Jul 30, 2025

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
Maximum velocity projections within 30 seconds: a combination of real-time three-directional flow MRI and
Jost M Kollmeier1, Oleksandr Kalentev1, Maaike van Zalk1
1Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Abstract:
This work is a proof-of-concept realization of a novel technique for rapid volumetric acquisition, reconstruction, and visualization of three-directional (3dir) flow velocities. The technique combines real-time 3dir phase-contrast (PC) flow magnetic resonance imaging (MRI) with real-time cross-sectional volume coverage. It offers a rapid examination without dependence on electrocardiography (ECG) or respiratory gating during a continuous image acquisition at up to 16 fps. Real-time flow MRI utilizes pronounced radial undersampling and a model-based nonlinear inverse reconstruction. Volume coverage is achieved by automatically advancing the slice position of each PC acquisition by a small percentage of the slice thickness. Post-processing involves the calculation of maximum intensity projections along the slice dimension resulting in six direction-selective velocity maps and a maximum speed map. Preliminary applications to healthy subjects at 3 T comprise mapping of the carotid arteries and cranial vessels at 1.0 mm in-plane resolution within 30 s as well as of the aortic arch at 1.6 mm resolution within 20 s. In conclusion, the proposed method for rapid mapping of 3dir flow velocities offers a quick assessment of the vasculature either to provide a first clinical survey or to plan for more detailed studies.

