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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jul 30, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Management of Malignant Glaucoma.

Reza Sadeghi1, Ali Momeni1, Ghasem Fakhraie1

  • 1Glaucoma Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Current Ophthalmology
|May 14, 2023
PubMed
Summary

Malignant glaucoma treatment varies, with surgery being most effective. Pars plana vitrectomy with irido-zonulo-capsulectomy shows the best outcomes for this severe eye condition.

Keywords:
Fluid misdirection syndromeLaser therapyMalignant glaucomaMedical interventionSurgical intervention

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Area of Science:

  • Ophthalmology
  • Glaucoma Research

Background:

  • Malignant glaucoma, also known as fluid misdirection syndrome, is a severe ocular condition.
  • It can arise spontaneously or after surgical procedures.
  • The pathophysiology involves complex and debated mechanisms.

Purpose of the Study:

  • To review and compare the effectiveness of various invasive and noninvasive treatment strategies for malignant glaucoma.
  • To outline current knowledge on the nonsurgical and surgical management of this condition.

Main Methods:

  • A comprehensive literature search was conducted using PubMed and Google Scholar.
  • Articles related to glaucoma were reviewed up to 2022.
  • This review synthesizes current evidence on malignant glaucoma management.

Main Results:

  • Nonsurgical treatments (medications, laser therapy) offer temporary relief.
  • Surgical interventions are generally more effective for malignant glaucoma.
  • Numerous surgical techniques exist, but comparative studies are limited.

Conclusions:

  • Pars plana vitrectomy with irido-zonulo-capsulectomy demonstrates the most favorable outcomes.
  • Further research is needed to compare the effectiveness and recurrence rates of different surgical methods.
  • Factors influencing surgical outcomes and the necessity of treating the fellow eye require consideration.