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Updated: Jul 30, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Tissue-specific range uncertainty estimation in proton therapy.

Casper Dueholm Vestergaard¹, Ludvig Paul Muren¹, Ulrik Vindelev Elstrøm¹

¹Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.

Physics and Imaging in Radiation Oncology

|May 14, 2023

Summary

This summary is machine-generated.

Tissue-specific uncertainties in proton therapy improve range margin accuracy compared to fixed uncertainties. This study quantifies these differences, suggesting tailored margins for better treatment precision.

Keywords:

Patient specific range uncertainty Proton range uncertainty Proton therapy Treatment planning

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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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Published on: June 7, 2015

Area of Science:

Medical Physics
Radiation Oncology
Biomedical Engineering

Background:

Proton therapy's sensitivity to range uncertainties necessitates accurate margin calculations.
Current methods often use tissue-independent uncertainties, which may not reflect actual variations.
Tissue-specific uncertainties in stopping power ratio (SPR) have been proposed to improve accuracy.

Purpose of the Study:

To compare range margins derived from tissue-specific SPR uncertainties versus fixed (tissue-independent or composite) uncertainties.
To quantify tissue-specific SPR uncertainties across different tissue densities (low, medium, high).
To evaluate the impact of these different uncertainty approaches on clinical proton therapy plans.

Main Methods:

Calculated tissue-specific SPR uncertainties based on imaging, CT number, and SPR estimation for low, medium, and high-density tissues.
Developed four clinical proton therapy plans for different tumor sites.
Recomputed plans using both tissue-specific and fixed SPR uncertainties, comparing dose-volume histogram parameters for targets and organs-at-risk.

Main Results:

Quantified SPR uncertainties: 7.0% (low), 1.0% (medium), and 1.3% (high density).
Observed plan differences primarily near the target volume when comparing tissue-specific vs. fixed uncertainties.
Found that composite uncertainties better represented tissue-specific uncertainties than tissue-independent ones.

Conclusions:

Tissue-specific SPR uncertainties differ significantly across tissue densities, suggesting potential for more precise range margins in proton therapy.
While differences exist between tissue-specific and fixed uncertainty applications, a fixed uncertainty may suffice if appropriately scaled to the body region.
This research highlights the importance of considering tissue heterogeneity for optimizing proton therapy range margins.