Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

4.8K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
4.8K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

4.8K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Universal Model to Align Heterochrony of Chondrogenesis Across Species.

Tissue engineering. Part A·2026
Same author

A DNA aptamer targeting RANKL and its nanoparticle-mediated delivery ameliorate osteoporotic bone loss.

International journal of biological macromolecules·2026
Same author

CHAC2-mediated glutathione metabolic reprogramming drives N1 polarization of bone marrow neutrophils and exacerbates inflammatory comorbidities.

International journal of oral science·2026
Same author

Aptamer-functionalized apoptotic vesicles ameliorate osteoarthritis via resuming mitochondria OXPHOS of chondrocytes.

Science advances·2026
Same author

Resistance to Fenoxaprop-P-ethyl in Wild Oats May Involve GST-Mediated Enhanced Antioxidant Capacity.

Journal of agricultural and food chemistry·2026
Same author

[Dynamic stretching promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in three-dimensional culture].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2026

Related Experiment Video

Updated: Jul 30, 2025

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

1.5K

Organoid Culture Development for Skeletal Systems.

Jia Qing1, Qian Guo1, Longwei Lv1

  • 1Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Haidian District, Beijing, China.

Tissue Engineering. Part B, Reviews
|May 15, 2023
PubMed
Summary

Organoid models offer advanced in vitro research capabilities. Developing skeletal organoids faces challenges in stem cell heterogeneity and microenvironment, requiring further matrix research for progress.

Keywords:
3D model systemsorganoidspluripotent stem cellsskeletal stem cellsskeletal systems

More Related Videos

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

492
A High-Throughput Platform for Culture and 3D Imaging of Organoids
07:42

A High-Throughput Platform for Culture and 3D Imaging of Organoids

Published on: October 14, 2022

2.8K

Related Experiment Videos

Last Updated: Jul 30, 2025

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
03:35

Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

Published on: June 21, 2024

1.5K
In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

492
A High-Throughput Platform for Culture and 3D Imaging of Organoids
07:42

A High-Throughput Platform for Culture and 3D Imaging of Organoids

Published on: October 14, 2022

2.8K

Area of Science:

  • Biomedical Engineering
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Organoids are advanced 3D in vitro models with self-organization and long-term culture capabilities.
  • They are crucial for regenerative medicine, disease research, and drug screening.
  • Skeletal system organoid development is complex due to bone tissue intricacy and stem cell heterogeneity.

Purpose of the Study:

  • To review progress in skeletal system organoid culture.
  • To analyze the status of skeletal stem cells, microenvironmental factors, and culture matrices.
  • To identify key challenges and future research directions for bone organoids.

Main Methods:

  • Literature review of current organoid culture systems.
  • Analysis of skeletal stem cell characteristics and microenvironmental influences.
  • Evaluation of potential organoid culture matrix candidates.

Main Results:

  • Organoids offer unique advantages over other 3D in vitro models.
  • Significant challenges exist in skeletal organoid generation, particularly concerning stem cell heterogeneity.
  • Understanding microenvironmental factors and optimizing culture matrices are critical.

Conclusions:

  • Bone organoid research presents substantial opportunities for biomedical advancements.
  • Addressing stem cell heterogeneity and microenvironmental factors is essential for robust skeletal organoid development.
  • Further investigation into culture matrix candidates will drive future progress in bone organoid technology.