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Updated: Jul 30, 2025
Determination of the Excitation and Coupling Rates Between Light Emitters and Surface Plasmon Polaritons
Published on: July 21, 2018
Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing
Cristina-Virginia Topor1,2, Mihaela Puiu1,2, Camelia Bala1,2
1Department of Analytical and Physical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., 030018 Bucharest, Romania.
Surface plasmon resonance (SPR) techniques offer sensitive, label-free detection but face challenges like poor stability. This review explores sensor modifications and nanomaterials to enhance SPR biosensor performance for trace analyte detection.
Area of Science:
- Analytical Chemistry
- Biotechnology
- Materials Science
Background:
- Surface Plasmon Resonance (SPR) is a powerful technique for sensitive, label-free detection of analytes.
- Current SPR biosensors face limitations including poor stability, non-specific adsorption, and loss of biomolecular activity.
- Addressing these challenges is crucial for advancing trace and ultra-trace analyte detection.
Purpose of the Study:
- To review recent advancements in SPR sensor modification and immobilization techniques.
- To discuss the application of novel nanomaterials for signal amplification in SPR.
- To evaluate the advantages and disadvantages of various SPR design strategies.
Main Methods:
- Review of sensor modification strategies.
- Analysis of biomolecule immobilization techniques.
- Investigation of nanomaterials (2D nanomaterials, gold nanostructures, magnetic nanoparticles) for signal enhancement.
Main Results:
- Progress in sensor surface functionalization and biomolecule immobilization has been achieved.
- Novel nanomaterials show promise for amplifying SPR signals.
- Various design strategies offer different trade-offs in terms of sensitivity, stability, and specificity.
Conclusions:
- Optimized sensor design and advanced nanomaterials are key to overcoming current SPR limitations.
- Further research into stability and non-specific adsorption is needed for robust ultra-trace detection.
- SPR technology continues to evolve, offering enhanced capabilities for biosensing applications.
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