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Functional Nanopores Enabled with DNA
Yongzheng Xing1, Alexia Rottensteiner1, Jonah Ciccone1
1Department of Chemistry, Institute for Structural and Molecular Biology, University College London, London, WC1H 0AJ, UK.
Angewandte Chemie (International Ed. in English)
|May 15, 2023
Summary
Functional DNA nanopores offer expanded capabilities for single-molecule sensing and nucleic acid sequencing. DNA nanotechnology enhances existing pores and creates novel ones, opening new research and application avenues.
Area of Science:
- Biophysics
- Synthetic Biology
- Nanotechnology
Background:
- Membrane-spanning nanopores are crucial for label-free single-molecule sensing and nucleic acid sequencing.
- Both natural protein/peptide pores and synthetic inorganic nanopores have limitations.
- DNA nanotechnology offers a powerful approach to overcome these limitations.
Purpose of the Study:
- To review advancements in functional DNA nanopores.
- To highlight the expansion of nanopore capabilities using DNA nanotechnology.
- To outline emerging applications for DNA nanopores.
Main Methods:
- Functionalization of existing nanopores with DNA strands.
- De novo creation of nanopores using DNA nanotechnology principles.
- Review of current literature on DNA-based nanopore development.
Main Results:
- DNA functionalization significantly expands the structural and functional diversity of nanopores.
- Novel classes of DNA nanopores are being engineered with tailored properties.
- These advancements are enabling new applications in sensing and sequencing.
Conclusions:
- Functional DNA nanopores represent a rapidly developing field with immense potential.
- DNA nanotechnology is key to unlocking next-generation nanopore applications.
- Further research promises expanded utility in biological and technological fields.
