Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Plasma amiodarone concentrations during intravenous infusion.

A H Watt, A Hutchings, M R Stephens

British Journal of Clinical Pharmacology

|May 1, 1986

Summary

Intravenous amiodarone dosing may need adjustment. This study found plasma amiodarone concentrations below therapeutic levels in some patients, suggesting higher doses might be needed for optimal antiarrhythmic benefit.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An Approach for Combining Clinical Judgment with Machine Learning to Inform Medical Decision Making: Analysis of Nonemergency Surgery Strategies for Acute Appendicitis in Patients with Multiple Long-Term Conditions.

Medical decision making : an international journal of the Society for Medical Decision Making·2024

Same author

Local Instrumental Variable Methods to Address Confounding and Heterogeneity when Using Electronic Health Records: An Application to Emergency Surgery.

Medical decision making : an international journal of the Society for Medical Decision Making·2022

Same author

Effectiveness of emergency surgery for five common acute conditions: an instrumental variable analysis of a national routine database.

Anaesthesia·2022

Same author

Ethnic variations in the risk of hypoglycaemia among people with Type 2 diabetes prescribed insulins and/or sulfonylureas: a historical cohort study using general practice-recorded data.

Diabetic medicine : a journal of the British Diabetic Association·2018

Same author

A change in the trend in dosulepin usage following the introduction of a prescribing indicator but not after two national safety warnings.

Journal of clinical pharmacy and therapeutics·2016

Same author

A comparative study of methyldopa and labetalol in the treatment of hypertension.

British journal of clinical pharmacology·2015

Area of Science:

Pharmacology
Cardiology
Clinical Pharmacy

Background:

Amiodarone is a critical antiarrhythmic medication.
Its pharmacokinetic profile requires further elucidation for optimal therapeutic use.
Understanding plasma concentrations is essential for drug efficacy.

Purpose of the Study:

To characterize amiodarone and desethylamiodarone plasma concentrations.
To evaluate a standard intravenous amiodarone infusion regimen.
To compare observed concentrations against the suggested therapeutic range.

Main Methods:

Eight patients received intravenous amiodarone.
Infusion rates were 175 mg/h for 2 hours, then 50 mg/h for 46 hours.
Plasma concentrations of amiodarone and desethylamiodarone were measured.

Related Experiment Videos

Main Results:

Plasma concentrations fell below the 1.0-2.5 mg/L therapeutic range in at least 3 of 8 patients.
Subtherapeutic levels were observed between 3 and 16 hours post-infusion initiation.
Individual patient pharmacokinetic variability was noted.

Conclusions:

Current intravenous amiodarone dosing regimens may be insufficient.
Higher doses might be required to achieve therapeutic plasma concentrations.
Further research into optimizing amiodarone dosing is warranted.