Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synteny and Evolution02:31

Synteny and Evolution

3.3K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.3K
Eukaryotic Evolution01:24

Eukaryotic Evolution

35.2K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
35.2K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.2K
The Evidence for Evolution02:55

The Evidence for Evolution

43.1K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
43.1K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.9K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.9K
Non-equilibrium in the Cell01:16

Non-equilibrium in the Cell

4.5K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multinucleation as a recurring evolutionary strategy for scaling and plasticity.

Current biology : CB·2026
Same author

Molecular pathways for learning in the single-cell Stentor coeruleus.

Current biology : CB·2026
Same author

Septin-mediated coupling of protein import and division during chloroplast evolution.

bioRxiv : the preprint server for biology·2026
Same author

Experimental Evolution of Yeast Reveals Trade-offs Between Early and Late Stationary Phase.

bioRxiv : the preprint server for biology·2026
Same author

Evolutionary cell biology comes of age.

Journal of cell science·2025
Same author

A geothermal amoeba sets a new upper temperature limit for eukaryotes.

bioRxiv : the preprint server for biology·2025
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Related Experiment Video

Updated: Jul 30, 2025

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
06:03

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Published on: September 20, 2016

14.5K

Experimental evolution for cell biology.

Jana Helsen1, Gavin Sherlock2, Gautam Dey3

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Cell Biology and Biophysics, European Molecular Biology Laboratory, Heidelberg, Germany.

Trends in Cell Biology
|May 15, 2023
PubMed
Summary
This summary is machine-generated.

Laboratory evolution offers new experimental validation for evolutionary cell biology. This approach, focusing on single cells, can address fundamental questions about cellular functions and regulatory networks.

Keywords:
adaptationevolutionary cell biologyevolutionary dynamicsevolutionary innovationexperimental design

More Related Videos

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.4K
Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
08:11

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Published on: June 14, 2024

832

Related Experiment Videos

Last Updated: Jul 30, 2025

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat
06:03

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

Published on: September 20, 2016

14.5K
Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.4K
Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution
08:11

Author Spotlight: Understanding Microbe Adaptation Using Innovative Techniques for Exploring Thermophilic Evolution

Published on: June 14, 2024

832

Area of Science:

  • Evolutionary cell biology
  • Experimental evolution
  • Genomics

Background:

  • Evolutionary cell biology investigates cellular origins and functions using evolutionary principles.
  • Current methods rely on comparative genomics and analysis of extant diversity, limiting experimental validation.
  • A gap exists in experimentally testing evolutionary hypotheses in cell biology.

Purpose of the Study:

  • To explore the potential of experimental laboratory evolution in evolutionary cell biology.
  • To provide a framework for adapting laboratory evolution protocols for cell biology research.
  • To address long-standing questions in cell biology using novel experimental approaches.

Main Methods:

  • Drawing inspiration from studies combining laboratory evolution with cell biological assays.
  • Focusing on experimental evolution approaches applicable to single cells.
  • Developing a generalizable template for experimental evolution protocols.

Main Results:

  • Experimental laboratory evolution can significantly augment the evolutionary cell biology toolbox.
  • Combining laboratory evolution with cell biological assays offers new avenues for research.
  • The proposed template facilitates fresh insights into cellular evolution.

Conclusions:

  • Experimental laboratory evolution is a promising approach for advancing evolutionary cell biology.
  • This methodology enhances the ability to experimentally validate evolutionary hypotheses.
  • The adaptable template can be widely applied to address key questions in cell biology.