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Updated: Jul 30, 2025

Murine Heterotopic Heart Transplant Technique
Published on: July 8, 2014
Pediatric Heart Transplant Rejection After COVID-19 Infection
Erin V Shea1, Natalie L Sinicropi2, Matthew F Cusick3
1Pediatric Cardiology, Duke University Medical Center.
Background:
Infections have been associated with rejection episodes in solid organ transplant recipients. We report an association between COVID-19 infection and heart transplant (HT) rejection.
Case Description:
The patient was 14 years old and 6.5 years post-HT. He developed symptoms of rejection within 2 weeks of COVID exposure and presumed infection.
Conclusions:
In this case, COVID-19 infection closely preceded significant rejection and graft dysfunction. Further study is needed to establish a correlation between COVID-19 infection and rejection in HT patients.
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