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Updated: Jul 30, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.5K
Does periodontitis affect respiratory health?
1Dental Core Trainee, East Lancs NHS Hospitals Trust, Lancashire, UK. mohammed.adam@elht.nhs.uk.
Evidence-Based Dentistry
|May 15, 2023
Summary
Periodontitis is linked to chronic obstructive pulmonary disease and obstructive sleep apnea. Periodontal therapy may improve outcomes for these conditions, as well as asthma and community-acquired pneumonia.
Area of Science:
- Oral Health and Respiratory Medicine
- Systematic Review and Meta-Analysis
Background:
- Periodontitis, a chronic inflammatory condition, is increasingly recognized for its potential systemic effects.
- Respiratory diseases, including COPD, OSA, asthma, COVID-19, and CAP, share common risk factors and inflammatory pathways with periodontitis.
Purpose of the Study:
- To systematically review and meta-analyze the association between periodontitis and respiratory diseases.
- To evaluate the impact of periodontal therapy on respiratory disease outcomes.
Main Methods:
- Systematic search of PubMed, Scopus, and Cochrane Library up to October 2021.
- Inclusion of cross-sectional, cohort, case-control, and clinical trial studies.
- Meta-analyses performed on studies with sufficient data, using fixed and random effects models.
Main Results:
- Significant positive associations found between periodontitis and chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA).
- No significant association was identified between periodontitis and asthma.
- Four studies indicated positive effects of periodontal treatment on COPD, asthma, and community-acquired pneumonia (CAP).
Conclusions:
- Periodontitis is associated with an increased prevalence of COPD and OSA.
- Periodontal therapy shows potential benefits for managing certain respiratory conditions.
- Further research is warranted to elucidate the complex interplay between oral health and respiratory diseases.
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