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Related Experiment Video

Updated: Jul 30, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Does periodontitis affect respiratory health?

Mohammed Adam¹

¹Dental Core Trainee, East Lancs NHS Hospitals Trust, Lancashire, UK. mohammed.adam@elht.nhs.uk.

Evidence-Based Dentistry

|May 15, 2023

Summary

Periodontitis is linked to chronic obstructive pulmonary disease and obstructive sleep apnea. Periodontal therapy may improve outcomes for these conditions, as well as asthma and community-acquired pneumonia.

Area of Science:

Oral Health and Respiratory Medicine
Systematic Review and Meta-Analysis

Background:

Periodontitis, a chronic inflammatory condition, is increasingly recognized for its potential systemic effects.
Respiratory diseases, including COPD, OSA, asthma, COVID-19, and CAP, share common risk factors and inflammatory pathways with periodontitis.

Purpose of the Study:

To systematically review and meta-analyze the association between periodontitis and respiratory diseases.
To evaluate the impact of periodontal therapy on respiratory disease outcomes.

Main Methods:

Systematic search of PubMed, Scopus, and Cochrane Library up to October 2021.
Inclusion of cross-sectional, cohort, case-control, and clinical trial studies.
Meta-analyses performed on studies with sufficient data, using fixed and random effects models.

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Main Results:

Significant positive associations found between periodontitis and chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA).
No significant association was identified between periodontitis and asthma.
Four studies indicated positive effects of periodontal treatment on COPD, asthma, and community-acquired pneumonia (CAP).

Conclusions:

Periodontitis is associated with an increased prevalence of COPD and OSA.
Periodontal therapy shows potential benefits for managing certain respiratory conditions.
Further research is warranted to elucidate the complex interplay between oral health and respiratory diseases.