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Updated: Jul 30, 2025
13:22
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
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Protein kinases: drug targets for immunological disorders
Leslie Castelo-Soccio1, Hanna Kim2, Massimo Gadina3
1Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Nature Reviews. Immunology
|May 15, 2023
Summary
Small molecule inhibitors targeting protein kinases are effective treatments for immune-mediated diseases. Janus kinase (JAK) and TEC family kinase inhibitors show promise in autoimmune conditions and cancers.
Area of Science:
- Immunology
- Pharmacology
- Cell Biology
Background:
- Protein kinases are crucial for immune cell activation and signal transduction.
- Targeting kinases has emerged as a successful therapeutic strategy for cancer and immune-mediated diseases.
Purpose of the Study:
- To review small molecule inhibitors targeting protein kinases in immune cells.
- To focus on inhibitors approved for immune-mediated diseases and lessons learned.
Main Methods:
- Literature review of small molecule kinase inhibitors.
- Analysis of approved drugs for immune-mediated diseases and related conditions.
Main Results:
- Janus kinase (JAK) inhibitors are approved for autoimmune/allergic diseases and COVID-19.
- TEC family kinase inhibitors (including Bruton's tyrosine kinase inhibitors) are approved for hematologic malignancies and graft-versus-host disease.
Conclusions:
- Kinase inhibitors are valuable therapeutics for immune-mediated diseases.
- Selectivity and genetic information play key roles in efficacy and safety.
- Ongoing development of novel kinase inhibitors and targeting strategies continues.
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