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Area of Science:

  • Genomic Medicine
  • Medical Communication
  • Psychosocial Aspects of Health

Background:

  • Prognosis research in medicine often centers on end-of-life care.
  • Genomic technology is increasingly used as a prognostic tool, particularly in contexts like pregnancy termination and neonatal palliation.
  • The implications of genomic results for patients who live and plan for their futures are less understood.

Purpose of the Study:

  • To highlight the need for understanding and managing prognostic implications of genomic testing, especially when conducted in a screening context.
  • To explore the psychosocial and communicational aspects of prognosis in genomic medicine.
  • To provide an interdisciplinary perspective on prognostication across the lifespan, from neonates to adults.

Main Methods:

  • Literature review and synthesis of existing research on prognosis and genomic medicine.
  • Interdisciplinary and inter-specialty perspective.
  • Discussion of prognostic information management from neonatal to adult periods.

Main Results:

  • Genomic testing provides broad, early, yet complex and uncertain prognostic information.
  • Understanding of prognosis in symptomatic populations offers valuable insights for screening contexts.
  • Longitudinal management of prognostic information is essential in genomic medicine.

Conclusions:

  • Researchers and clinicians must address the prognostic implications of early and screening-based genomic testing.
  • Lessons from symptomatic populations can inform research and practice in screening contexts.
  • A lifespan approach is necessary for effectively managing prognostic information in genomic medicine.