Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deciphering protein mutation-phenotype linkages from CRISPR-based tiling mutagenesis screens.

Cell systems·2026

Same author

Deconstructing Multi-Scale Hybrid Fiber-Reinforced Coarse Aggregate UHPC: From Pore Structure Tailoring to Cross-Scale Toughening.

Materials (Basel, Switzerland)·2026

Same author

Impact of Typical Somatic Gene Mutation Characteristics on Homologous Recombination Deficiency in Breast Cancer.

Clinical breast cancer·2026

Same author

Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer.

bioRxiv : the preprint server for biology·2026

Same author

Opposing effects of arginine on Fc- and VH3-mediated antibody-Protein A interactions.

Journal of chromatography. A·2026

Same author

Human Pancreatic Cancer Organoids.

Cell proliferation·2026

Same journal

mRNA-LNP delivery of individual longevity genes mitigates doxorubicin-induced progeroid phenotypes.

Protein & cell·2026

Same journal

Targeting the TBK1-p62 condensate axis restores sensitivity to EGFR-TKIs in resistant lung cancer.

Protein & cell·2026

Same journal

Recent progresses in cancer multidrug resistance and therapeutic options associated with protein damage response.

Protein & cell·2026

Same journal

LncRNA Gas5 directs SUV39H2 to establish heterochromatin and maintain genome stability.

Protein & cell·2026

Same journal

3D chromatin dynamics in cellular neuroendocrine transformation.

Protein & cell·2026

Same journal

Topology-Driven Activation of the GLP-1 Receptor Promotes Adipose Tissue Browning.

Protein & cell·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 30, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

Microbial sensing in the intestine.

Tingting Wan¹, Yalong Wang¹, Kaixin He¹

¹Division of Life Sciences and Medicine, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Basic Medical Sciences, University of Science and Technology of China, Hefei 230027, China.

|May 16, 2023

Summary

This summary is machine-generated.

The gut immune system senses microbes via specific receptors. Disruptions in this sensing mechanism can lead to diseases like inflammatory bowel disease (IBD).

Keywords:

enteric viruses gut microbiota immune cells inflammatory bowel disease intestinal epithelial cells mucosal immunology pattern recognition receptors protein-coupled receptors

More Related Videos

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids

Published on: December 18, 2017

Related Experiment Videos

Last Updated: Jul 30, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

Published on: June 30, 2021

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids

Published on: December 18, 2017

Area of Science:

Immunology
Microbiology
Gastroenterology

Background:

The gut microbiota is crucial for host health, influencing the immune system and maintaining intestinal homeostasis.
Immune-microbiota interactions are vital for symbiotic relationships within the gut.
Sensing gut microbes by the host immune system is the initial step in this interaction.

Conclusions:

Effective microbial sensing by the host immune system is essential for maintaining gut health.
Dysregulation of these sensing pathways can trigger inflammatory conditions.
Understanding these interactions is critical for developing therapeutic strategies for IBD and other gut-related diseases.