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Updated: Jul 30, 2025

Nanopodia - Thin, Fragile Membrane Projections with Roles in Cell Movement and Intercellular Interactions
Published on: April 3, 2014
Tetraspanin-enriched microdomains: The building blocks of migrasomes
Yuwei Huang1, Li Yu1
1State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, School of Life Science, Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University, Beijing, China.
Abstract:
The migrasome is a newly discovered organelle of migrating cells. Migrasomes play diverse physiological roles including mitochondrial quality control, lateral transfer of material between cells, and delivery of signaling molecules to spatially defined locations. The formation of migrasomes is dependent on tetraspanins, a group of membrane proteins containing four transmembrane domains, which form membrane microdomains named tetraspanin-enriched microdomains (TEMs). In this review, we will discuss the mechanisms for migrasome biogenesis, with a focus on the role of TEMs and the organizing principles underlying the formation of TEMs.
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