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Updated: Jul 30, 2025
High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
Published on: January 19, 2022
Cross-sectional evaluation of the saccharin transit time test for primary ciliary dyskinesia: did we discard this
Mariana Dalbo Contrera Toro1, Erica Ortiz2, Fernando Augusto Lima Marson3
1MD, MSc. PhD Student, Department of Otolaryngology, Faculty of Medical Sciences, Universidade Estadual de Campinas (UNICAMP), Campinas (SP), Brazil.
Background:
Primary ciliary dyskinesia (PCD) is a rare and heterogeneous disease that is difficult to diagnose and requires complex and expensive diagnostic tools. The saccharin transit time test is a simple and inexpensive tool that may assist in screening patients with PCD.
Objectives:
This study aimed to compare changes in the electron microscopy findings with clinical variables and saccharin tests in individuals diagnosed with clinical PCD (cPCD) and a control group.
Design And Setting:
An observational cross-sectional study was conducted in an otorhinolaryngology outpatient clinic from August 2012 to April 2021.
Method:
Patients with cPCD underwent clinical screening questionnaires, nasal endoscopy, the saccharin transit time test, and nasal biopsy for transmission electron microscopy.
Results:
Thirty-four patients with cPCD were evaluated. The most prevalent clinical comorbidities in the cPCD group were recurrent pneumonia, bronchiectasis, and chronic rhinosinusitis. Electron microscopy confirmed the clinical diagnosis of PCD in 16 of the 34 (47.1%) patients.
Conclusion:
The saccharin test could assist in screening patients with PCD due to its association with clinical alterations related to PCD.
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