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Updated: Jul 30, 2025

Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
[Post-transplant lymphoproliferative disorders]
Sabrina Forsell1, Noémie Lang1,2
1Faculté de médecine, Université de Genève, 1211 Genève 4.
Abstract:
Post-transplant lymphoproliferative disorders (PTLD) represent a typical complication of transplant recipients. Their incidence varies according to the recipient's characteristics and the type of transplanted organ. Their pathogenesis is strongly related to a disbalance between reduced T-cell immune surveillance to avoid graft rejection, and the reactivation of the oncogenic Epstein-Barr virus (EBV) within B lymphocytes, leading to uncontrolled B-cell proliferation and malignant transformation. PTLD represent a spectrum of various histological entities with distinct prognosis. Clinical management mainly focuses on their surveillance and therapeutic strategy is risk-adapted. This review aims to shed light on these rare pathologies whose early detection could greatly improve the prognosis of transplant patients.
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