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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

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Published on: May 10, 2017

[Post-transplant lymphoproliferative disorders].

Sabrina Forsell¹, Noémie Lang^1,2

¹Faculté de médecine, Université de Genève, 1211 Genève 4.

Revue Medicale Suisse

|May 17, 2023

Summary

Post-transplant lymphoproliferative disorders (PTLD) are common in transplant recipients. Early detection and risk-adapted management of these Epstein-Barr virus-related B-cell cancers are crucial for improving patient outcomes.

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Area of Science:

Immunology
Oncology
Transplantation Medicine

Background:

Post-transplant lymphoproliferative disorders (PTLD) are a significant complication following organ transplantation.
PTLD incidence varies based on recipient factors and transplanted organ type.
The pathogenesis involves a T-cell immune surveillance imbalance and Epstein-Barr virus (EBV) reactivation in B lymphocytes.

Conclusions:

PTLD requires careful surveillance and tailored treatment approaches.
Understanding PTLD pathogenesis is key to managing transplant recipients.
Early diagnosis significantly enhances the prognosis for transplant patients with PTLD.