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Published on: July 20, 2022
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Kidney health and function with left ventricular assist devices
Leonardo Pozo Garcia1, Carl P Walther
1Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Current Opinion in Nephrology and Hypertension
|May 17, 2023
Summary
Mechanical circulatory support (MCS) can impact kidney function in advanced heart failure patients. While some improve after durable left ventricular assist device (LVAD) implantation, varied kidney outcomes highlight the need for further research.
Area of Science:
- Cardiology
- Nephrology
- Medical Devices
Background:
- Mechanical circulatory support (MCS) encompasses evolving therapies for cardiac conditions, including advanced heart failure.
- Left ventricular assist devices (LVADs) are primary MCS devices supporting left ventricle function.
- Kidney dysfunction is prevalent in MCS patients, but the specific impact of MCS on renal health remains unclear.
Approach:
- This review synthesizes current understanding of kidney dysfunction in MCS patients.
- It examines various causes of kidney issues, from pre-existing conditions to device-related complications.
- The review highlights recent findings on kidney outcomes following durable LVAD implantation.
Key Points:
- Kidney dysfunction in MCS patients arises from diverse factors including systemic disorders, acute illness, and procedural/device complications.
- Durable LVAD implantation often leads to improved kidney function, but outcomes vary significantly.
- Novel patterns of kidney outcomes in LVAD recipients have been identified.
Conclusions:
- The relationship between MCS and kidney health requires deeper investigation due to uncertain underlying pathophysiology.
- Understanding MCS's effect on renal function is crucial for enhancing patient outcomes.
- Further research into MCS and kidney health is essential in this rapidly advancing field.
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