Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

27
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
27
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

26
Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
26
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

189
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
189
Endotracheal Intubation I: Procedure01:15

Endotracheal Intubation I: Procedure

2.0K
Endotracheal or ET intubation is a critical medical procedure used to secure a patient's airway, often in acute respiratory distress, apnea, upper airway obstruction, ineffective clearance of secretions, high risk for aspiration, or during general anesthesia.
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
2.0K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

1.5K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.5K
General External Flow Characteristics01:26

General External Flow Characteristics

240
The study of external flow is essential for creating structures and objects that interact efficiently and safely with moving fluids, such as air or water. When a body is immersed in a flowing fluid, it experiences two primary forces: drag, which opposes motion along the flow direction, and lift, which acts perpendicular to the flow. The shape, size, and orientation of the object influence these forces.Streamlined and Blunt Bodies in External FlowObjects in fluid flow are classified as...
240

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Solution of C-Section Associated Surgical Site Infection in LMICs: A Narrative Review.

Pakistan journal of medical sciences·2026
Same author

Factors Affecting Quality Control (QC) Failure Rates in Somatic Breast Cancer (BRCA) Gene Testing in Castrate Resistant Prostate Cancer: Experiences From an Australian Cancer Care Centre.

Asia-Pacific journal of clinical oncology·2025
Same author

Method for Targeted Cellular Seeding of Tubular Tissue-Engineered Scaffolds for Tracheal Regeneration Approaches.

ACS biomaterials science & engineering·2025
Same author

Colorectal cancer in pregnancy: case discussions and real-world data as well as literature review on current knowledge.

The oncologist·2025
Same author

Ruptured uterine pyomyoma with multiorgan dysfunction syndrome.

BMJ case reports·2025
Same author

Palliative management of nausea and vomiting in advanced cancer.

Australian journal of general practice·2024

Related Experiment Video

Updated: Jul 30, 2025

Procedure for Lung Engineering
12:50

Procedure for Lung Engineering

Published on: March 8, 2011

46.8K

Engineering Large Airways.

Tehreem Khalid1,2,3, Cian O'Leary4,5,6

  • 1School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.

Advances in Experimental Medicine and Biology
|May 17, 2023
PubMed
Summary

Designing effective tracheal replacements requires matching native tissue mechanics. This study explores tracheal biomechanics and pressure forces to guide the development of better biomaterial scaffolds for trachea reconstruction.

Keywords:
BiomechanicsMechanical testingTrachea pressure

More Related Videos

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

2.7K
Engineered Lung Tissues Prepared from Decellularized Lung Slices
08:01

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Published on: January 21, 2022

3.6K

Related Experiment Videos

Last Updated: Jul 30, 2025

Procedure for Lung Engineering
12:50

Procedure for Lung Engineering

Published on: March 8, 2011

46.8K
Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue
11:01

Imaging-Guided Bioreactor for Generating Bioengineered Airway Tissue

Published on: April 6, 2022

2.7K
Engineered Lung Tissues Prepared from Decellularized Lung Slices
08:01

Engineered Lung Tissues Prepared from Decellularized Lung Slices

Published on: January 21, 2022

3.6K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biomedical Engineering

Background:

  • Trachea replacement implants often fail due to mismatched mechanical properties between native tissue and synthetic constructs.
  • The native trachea exhibits complex anisotropic biomechanical properties, integrating cartilage, smooth muscle, and ligaments for stability and dynamic deformation.
  • Lack of standardized biomechanical assessment protocols hinders the design of effective tracheal biomaterial scaffolds.

Purpose of the Study:

  • To analyze the pressure forces acting on the trachea during physiological processes.
  • To investigate the distinct biomechanical properties of the trachea's main structural components.
  • To provide guidance for designing tracheal substitutes with appropriate mechanical characteristics.

Main Methods:

  • Review of literature on tracheal biomechanics and pressure dynamics.
  • Analysis of the structural and functional roles of tracheal components (cartilage, muscle, ligament).
  • Discussion of methods for assessing tracheal tissue biomechanical properties.

Main Results:

  • Tracheal substitutes must withstand significant intra-thoracic pressure changes during respiration.
  • Implants need to allow radial deformation for functions like coughing and swallowing.
  • Understanding anisotropic properties is crucial for replicating native tissue function.

Conclusions:

  • Accurate quantification of tracheal biomechanics is essential for successful implant design.
  • Biomaterial scaffold development must consider both static and dynamic mechanical requirements.
  • This work highlights key biomechanical factors influencing tracheal construct design.