Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gross Anatomy of the Lungs

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Proteomic analysis reveals regional sex differences in healthy and fibrotic human lung.

bioRxiv : the preprint server for biology·2026

Same author

The importance of sex as a biological variable in pulmonary vascular research.

American journal of physiology. Lung cellular and molecular physiology·2026

Same author

Hydrogel-Embedded Precision-Cut Lung Slices Recapitulate Fibrotic Gene Expression and Enable Therapeutic Response Evaluation.

bioRxiv : the preprint server for biology·2026

Same author

Aberrant tissue mechanics and mechanotransduction during heart development in down syndrome.

Journal of biomechanics·2025

Same author

Evaluating How Exposure to Scientific Role Models and Work-Based Microbadging Influences STEM Career Mindsets in Underrepresented Groups.

Biomedical engineering education·2025

Same author

Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosis.

Acta biomaterialia·2025

Search research articles

Related Experiment Video

Updated: Jul 30, 2025

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Engineering Dynamic 3D Models of Lung.

Rachel Blomberg¹, Rukshika S Hewawasam¹, Predrag Šerbedžija¹

¹Department of Bioengineering, University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO, USA.

Advances in Experimental Medicine and Biology

|May 17, 2023

Summary

This summary is machine-generated.

Researchers are developing advanced in vitro models to study lung parenchyma, the critical site for gas exchange and chronic lung diseases. These models integrate biochemical, structural, and mechanical factors for better lung biology research.

Keywords:

Alveolar epithelial cells Biomaterials Biomechanics Extracellular matrix Hydrogels Lung fibroblasts Lung parenchyma Lung-on-a-chip Organoids Precision cut lung slices

More Related Videos

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

Published on: May 19, 2023

Author Spotlight: Advancing 3D Modeling for Enhanced Diagnosis and Treatment of Pulmonary Nodules in Early-Stage Lung Cancer

Author Spotlight: Advancing 3D Modeling for Enhanced Diagnosis and Treatment of Pulmonary Nodules in Early-Stage Lung Cancer

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Jul 30, 2025

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

Published on: May 19, 2023

Author Spotlight: Advancing 3D Modeling for Enhanced Diagnosis and Treatment of Pulmonary Nodules in Early-Stage Lung Cancer

Author Spotlight: Advancing 3D Modeling for Enhanced Diagnosis and Treatment of Pulmonary Nodules in Early-Stage Lung Cancer

Published on: October 13, 2023

Area of Science:

Pulmonary Medicine
Biomedical Engineering
Tissue Engineering

Background:

The lung parenchyma is vital for gas exchange and implicated in chronic lung diseases.
Accurate in vitro models are needed to study lung biology in health and disease.
Modeling lung parenchyma requires integrating biochemical, structural, and mechanical factors.

Purpose of the Study:

To provide an overview of diverse in vitro model systems for lung parenchyma.
To highlight scientific advances enabled by these lung models.
To discuss the strengths, weaknesses, and future directions of engineered lung systems.

Main Methods:

Review of various in vitro lung parenchyma model systems.
Discussion of synthetic and naturally derived hydrogel materials.
Analysis of precision-cut lung slices, organoids, and lung-on-a-chip devices.

Main Results:

Various engineered systems recapitulate features of lung parenchyma.
These models have facilitated scientific advances in lung research.
Different models offer unique strengths for studying lung biology.

Conclusions:

In vitro lung parenchyma models are valuable tools for biomedical research.
Continued development of these engineered systems holds promise for future discoveries.
Integrating multiple biological and physical cues enhances model fidelity.