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Related Experiment Videos

Collagen remodeling during decidualization in the mouse.

T M Zorn, E M Bevilacqua, P A Abrahamsohn

    Cell and Tissue Research
    |January 1, 1986
    PubMed
    Summary
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    During early pregnancy, mouse endometrial fibroblasts digest collagen intracellularly. Later, thicker collagen fibrils appear between decidual cells, indicating stromal remodeling.

    Area of Science:

    • Reproductive Biology
    • Cell Biology
    • Histology

    Background:

    • Collagen is a key structural protein in the endometrium.
    • Endometrial remodeling is crucial for successful pregnancy.
    • The precise role and dynamics of collagen during early pregnancy are not fully understood.

    Purpose of the Study:

    • To investigate the ultrastructural changes and distribution of collagen fibrils in the mouse endometrium during early pregnancy.
    • To elucidate the cellular mechanisms involved in collagen processing during endometrial remodeling.

    Main Methods:

    • Ultrastructural analysis of mouse endometrial tissues.
    • Lanthanum nitrate staining to identify intracytoplasmic structures.
    • Comparative analysis between virgin and pregnant mice (days 2-11).

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    Main Results:

    • Collagen-containing structures were observed within fibroblast cytoplasm on day 2 of pregnancy.
    • Intracytoplasmic collagen was associated with lysosome-like bodies, suggesting intracellular digestion.
    • A significant decrease in intercellular collagen was noted by day 4.
    • Thicker collagen fibrils (up to 300 nm) appeared between decidual cells from day 6 onwards, compared to virgin mice (40-68 nm).

    Conclusions:

    • Intracellular collagen digestion by fibroblasts occurs in the early pregnant endometrium.
    • This process is likely involved in endometrial stromal remodeling preceding decidualization.
    • Pregnancy induces significant alterations in endometrial collagen fibril size and distribution.