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Updated: Jul 30, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Pediatric Pasteurella canis endophthalmitis.

Shruthi Bathula¹, Manjushree Bhate², Joveeta Joseph³

¹Pediatric Ophthalmology, Strabismsus and Neuro-ophthalmology, LV Prasad Eye Institute, Hyderabad, India.

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus

|May 17, 2023

Summary

A rare Pasteurella canis infection caused endophthalmitis in an infant. This Gram-negative coccobacillus, typically found in animals, can lead to serious ocular infections, often from bites or scratches.

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Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Background:

Endophthalmitis is a severe intraocular inflammation, often caused by bacterial or fungal infections.
Pasteurella canis is a Gram-negative coccobacillus commonly found in the oral and gastrointestinal tracts of domestic animals like cats and dogs.
Ocular infections from Pasteurella species are typically linked to animal bites or scratches.

Observation:

This report details an unusual case of endophthalmitis in a 2-month-old infant.
The infant presented with an atypical clinical manifestation of the infection.

Findings:

The causative agent was identified as Pasteurella canis, a rare cause of endophthalmitis in this age group.
This case highlights a less common route of transmission or presentation of Pasteurella canis ocular infections.

Implications:

Early recognition of atypical Pasteurella canis infections is crucial for prompt diagnosis and treatment in infants.
Understanding the diverse clinical presentations of Pasteurella canis is important for ophthalmologists and pediatricians.
This case underscores the potential for zoonotic transmission of pathogens causing severe ocular disease in neonates and infants.