Related Experiment Video

Updated: Jul 30, 2025

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
09:12

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Published on: March 27, 2018

9.5K

Long-term outcomes after coronary artery bypass graft with or without surgical ventricular reconstruction in patients

Tao Yang1, Xin Yuan1, Baotong Li1

  • 1Department of Cardiovascular Surgery, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China.

Journal of Thoracic Disease
|May 17, 2023
PubMed

Insights

Coronary artery bypass graft (CABG) with surgical ventricular reconstruction (SVR) improves long-term outcomes for patients with chronic myocardial infarction (MI) and severe left ventricular (LV) dysfunction. This approach reduces heart failure rehospitalizations and enhances cardiovascular event-free survival compared to isolated CABG.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Cardiovascular Imaging

Background:

  • Patients with chronic myocardial infarction (MI) and severe left ventricular (LV) dysfunction face poor clinical outcomes.
  • Surgical ventricular reconstruction (SVR) is a potential treatment to improve LV function post-MI.
  • The efficacy of SVR combined with coronary artery bypass graft (CABG) versus isolated CABG (I-CABG) requires further investigation.

Purpose of the Study:

  • To compare the long-term outcomes of CABG with SVR versus I-CABG in patients with chronic MI and severe LV dysfunction.
  • To evaluate the impact of CABG+SVR on cardiovascular events and survival rates.
  • To assess the influence of SVR on rehospitalization rates for congestive heart failure (CHF).

Main Methods:

  • A prospective study involving 140 patients with chronic MI and severe LV dysfunction.
  • Patients underwent contrast-enhanced cardiovascular magnetic resonance imaging (CE-CMR) pre-operatively.
  • Comparison of outcomes between 70 patients who received CABG+SVR and 70 patients who received I-CABG.

Main Results:

  • No significant differences in baseline characteristics, LV function, or late gadolinium enhancement (LGE) between groups.
  • CABG+SVR group had longer cardiopulmonary bypass and ventilation times.
  • Mean follow-up of 123.1 months revealed fewer CHF rehospitalizations (4.3% vs. 19.1%) and higher cumulative cardiovascular event-free survival (87.0% vs. 67.6%) in the CABG+SVR group.
  • No significant difference in mortality rates was observed (2.9% vs. 4.4%).

Conclusions:

  • CABG+SVR and I-CABG demonstrate similar perioperative outcomes in this patient cohort.
  • CABG+SVR significantly reduces rehospitalizations for CHF and improves cumulative cardiovascular event-free survival.
  • SVR in conjunction with CABG offers significant long-term benefits for selected patients with chronic MI and severe LV dysfunction.
Abstract

Keywords:
Coronary artery bypass graft (CABG)contrast-enhanced cardiovascular magnetic resonance imaging (CE-CMR)left ventricular aneurysmsurgical ventricular reconstruction (SVR)

More Related Videos

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.1K
Author Spotlight: Enhancing Coronary Artery Revascularization05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

789

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
19
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
16
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
12
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
27