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Amdoparvovirus-associated disease in striped skunks (Mephitis mephitis)

Charles E Alex1, Katherine D Watson1, Maya Schlesinger1

  • 1University of California, Davis, Davis, CA.

Veterinary Pathology
|May 18, 2023
PubMed

Insights

Skunk amdoparvovirus (SKAV) infects many striped skunks, causing neurologic disease and inflammation in multiple organs. This study details SKAV

Area of Science:

  • Veterinary Virology
  • Wildlife Disease Ecology
  • Pathology

Background:

  • Aleutian mink disease virus (AMDV) is a well-studied amdoparvovirus (APV).
  • APV infections in carnivores beyond mink are poorly understood.
  • Skunk amdoparvovirus (SKAV) is a newly discovered APV with high prevalence in North American striped skunks.

Purpose of the Study:

  • To evaluate SKAV infection status in free-ranging California skunks.
  • To determine viral tissue distribution and associated lesions.
  • To compare SKAV pathology with AMDV.

Main Methods:

  • Necropsy and histopathological examination of 26 euthanized skunks.
  • Detection of SKAV in various tissues.
  • Analysis of lesions including nephritis, meningoencephalitis, myocarditis, and arteritis.

Main Results:

  • SKAV was detected in the majority of the skunk cohort.
  • Virus presence correlated with tubulointerstitial nephritis, meningoencephalitis, myocarditis, and arteritis.
  • SKAV-associated lesions showed similarities and distinct differences compared to AMDV, particularly in the kidneys.

Conclusions:

  • SKAV is prevalent in striped skunks and associated with significant pathology.
  • SKAV causes a spectrum of inflammatory diseases in skunks.
  • Understanding SKAV pathogenesis is crucial for wildlife health and comparative virology.
Keywords:
Striped skunkamdoparvovirushistologyin situ hybridizationmephitis

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