Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Time sequence of anginal pain.

G Mattioli, G Cioni, C Andreoli

    Clinical Cardiology
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Chest pain attacks in angina at rest patients show a distinct circadian rhythm, peaking in the early morning. This pattern persists even with medication, though overall attack frequency decreases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Longitudinal data of neuropsychological profile in a cohort of Duchenne muscular dystrophy boys without cognitive impairment.

    Neuromuscular disorders : NMD·2021
    Same author

    A new protocol for assessing action observation and imitation abilities in children with Developmental Coordination Disorder: A feasibility and reliability study.

    Human movement science·2020
    Same author

    Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions.

    Neuromuscular disorders : NMD·2018
    Same author

    Network over-connectivity differentiates autism spectrum disorder from other developmental disorders in toddlers: A diffusion MRI study.

    Human brain mapping·2017
    Same author

    Diffusion Tractography Biomarkers of Pediatric Cerebellar Hypoplasia/Atrophy: Preliminary Results Using Constrained Spherical Deconvolution.

    AJNR. American journal of neuroradiology·2015
    Same author

    [Persistent hyperplastic primary vitreous: case report and literature review].

    La Clinica terapeutica·2014
    Same journal

    Comparing Ferric Carboxymaltose Versus Iron Sucrose in Patients with Heart Failure.

    Clinical cardiology·2026
    Same journal

    Beyond Rural Versus Urban: Referral Pathways and Structural Heart Programs May Influence Outcomes After Left Atrial Appendage Occlusion.

    Clinical cardiology·2026
    Same journal

    Strauss-Defined LBBB Identifies Patients With Improved Outcomes After CRT-D: A Comparative Cohort Study.

    Clinical cardiology·2026
    Same journal

    Does Serum γKlotho Truly Provide Incremental Prognostic Value Beyond Established Risk Predictors in Multivessel Coronary Artery Disease?

    Clinical cardiology·2026
    Same journal

    Associations of the C-Reactive Protein-Albumin-Lymphocyte Index, Red Cell Distribution Width-Albumin Ratio, and Blood Urea Nitrogen-Albumin Ratio With All-Cause and Cardiovascular Mortality Among Adults With Preclinical Heart Failure.

    Clinical cardiology·2026
    Same journal

    Real-World National Databases Versus Hypothesis-Driven Cohort Studies: A Reply to the Critique on the TURK-HF Registry Design.

    Clinical cardiology·2026
    See all related articles

    Area of Science:

    • Cardiology
    • Chronobiology
    • Internal Medicine

    Background:

    • Angina at rest is characterized by chest pain episodes.
    • Understanding the temporal patterns of these attacks is crucial for patient management.
    • Circadian rhythms influence various physiological processes, including cardiovascular events.

    Purpose of the Study:

    • To investigate the circadian rhythm of chest pain attacks in patients with angina at rest.
    • To evaluate the effect of anti-anginal therapies on the timing and frequency of these attacks.
    • To explore the relationship between the circadian distribution of anginal attacks and the extent of coronary artery disease.

    Main Methods:

    • 187 patients with angina at rest were monitored for 7 days without therapy (placebo) and then with therapy (nifedipine, metoprolol, or isosorbide dinitrate).

    Related Experiment Videos

  • A total of 1466 chest pain attacks were recorded during the placebo period.
  • Coronary angiography was performed on 76 patients to assess coronary damage.

    • Main Results:

    • The majority of chest pain attacks occurred between 5 and 8 A.M., with a lower incidence from 9 A.M. to 4 P.M.
    • Therapy reduced the frequency of painful episodes but did not alter the diurnal distribution.
    • Altered diurnal patterns were observed in patients with normal coronary arteries or one- to two-vessel disease, while three-vessel disease or left main stenosis showed a more uniform distribution.

    Conclusions:

    • Angina at rest exhibits a significant circadian variation in attack occurrence, predominantly in the early morning hours.
    • While anti-anginal medications reduce attack frequency, they do not modify the inherent circadian rhythm.
    • The extent of coronary artery disease influences the circadian distribution of anginal attacks, with more severe disease showing less distinct diurnal patterns.