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Related Concept Videos

Phases of Wound Repair01:28

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Related Experiment Video

Updated: Jul 30, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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Chronic Wound Healing Models.

Kiley Flynn1, Nouf N Mahmoud2,3, Shahriar Sharifi1

  • 1Department of Radiology and Precision Health Program, Michigan State University, East Lansing, Michigan 48824-1312, United States.

ACS Pharmacology & Translational Science
|May 18, 2023
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Summary

Choosing the right wound healing model is crucial for human research. This review analyzes various in vitro, in silico, and in vivo models, highlighting their strengths and limitations for translational studies.

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Area of Science:

  • Regenerative Medicine
  • Biomedical Engineering
  • Wound Healing Research

Background:

  • Wound healing research relies on diverse experimental models.
  • Translating findings from animal or in vitro models to human patients remains a significant challenge.
  • Existing literature lacks a comprehensive analysis of model systems' suitability for human wound healing.

Purpose of the Study:

  • To critically review and analyze commonly used wound healing models.
  • To discuss the advantages, limitations, and translational potential of various experimental approaches.
  • To explore emerging technologies for enhanced wound healing studies.

Main Methods:

  • Systematic literature review of in vitro, in silico, and in vivo wound healing models.
  • Analysis of experimental techniques and their relevance to human physiology.
  • Exploration of new technologies in wound healing research.

Main Results:

  • No single wound healing model is universally superior for human research.
  • Different models possess specific strengths for studying particular wound healing processes or stages.
  • Model selection requires careful consideration of species, model type, and human pathophysiology replication.

Conclusions:

  • The choice of wound healing model must align with the specific research question and desired translational outcome.
  • A combination of models may be necessary to fully understand complex wound healing mechanisms.
  • Future research should focus on developing and validating models with higher human relevance.