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Related Experiment Video

Updated: Jul 30, 2025

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

Swept-source multimode fiber imaging.

Benjamin Lochocki¹, Aleksandra Ivanina², Akje Bandhoe²

¹Nanoscale Imaging and Metrology, Advanced Research Center for Nanolithography (ARCNL), Science Park 106, 1098 XG, Amsterdam, The Netherlands. lochocki@arcnl.nl.

Scientific Reports

|May 18, 2023

Summary

This summary is machine-generated.

High-resolution imaging is achieved through flexible fibers using a swept-laser and speckle illumination. This scan-free method significantly reduces acquisition time for minimally invasive endoscopy and neuroimaging applications.

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Last Updated: Jul 30, 2025

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

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Published on: October 17, 2016

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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Area of Science:

Optical imaging
Biomedical engineering
Medical instrumentation

Background:

Flexible fiber probes are crucial for minimally invasive endoscopy.
Current imaging techniques often require mechanical scanning, limiting flexibility and increasing complexity.
Need for high-resolution imaging in confined or delicate anatomical regions.

Purpose of the Study:

To demonstrate high-resolution compressive imaging using a flexible multimode fiber.
To develop a mechanically scan-free imaging approach for enhanced endoscopic applications.
To reduce acquisition time and improve device simplicity for minimally invasive procedures.

Main Methods:

Utilized a custom-built swept-laser source with independent control over bandwidth and scanning range.
Employed wavelength-dependent speckle illumination for compressive imaging.
Implemented computational image reconstruction with a narrow sweeping bandwidth.

Main Results:

Achieved high-resolution imaging through an ultrathin and flexible fiber probe.
Demonstrated a mechanically scan-free approach, reducing acquisition time by 95% compared to conventional methods.
Confirmed the suitability of narrow-band visible spectrum illumination for fluorescence biomarker detection.

Conclusions:

The proposed method offers a simple and flexible solution for high-resolution, minimally invasive endoscopy.
This technique shows promise for applications like neuroimaging, particularly in detecting fluorescence biomarkers.
Scan-free imaging via flexible fibers represents a significant advancement in endoscopic imaging technology.