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FoxO1/NLRP3 Inflammasome Promotes Age-Related Alveolar Bone Resorption.
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Journal of Dental Research
|May 19, 2023
Summary
Forkhead transcription factor O1 (FoxO1) deficiency halts age-related alveolar bone loss by enhancing osteoblast differentiation. This suggests FoxO1 plays a key role in periodontitis and offers a potential therapeutic target.
Area of Science:
- Oral biology
- Gerontology
- Molecular biology
Background:
- Periodontitis is a common chronic oral disease exacerbated by aging.
- Aging involves chronic inflammation and contributes to alveolar bone loss.
- Forkhead transcription factor O1 (FoxO1) is crucial in cellular processes but its role in age-related bone loss is unknown.
Purpose of the Study:
- To investigate the role of FoxO1 in age-related alveolar bone resorption.
- To explore the therapeutic potential of targeting FoxO1 in periodontitis.
Main Methods:
- Generated osteoblast-specific FoxO1 knockout mice.
- Assessed alveolar bone loss and osteogenic potential in aged mice.
- Investigated the NLRP3 inflammasome pathway and reactive oxygen species (ROS) in osteoblasts.
Main Results:
- FoxO1 deficiency ameliorated age-related alveolar bone loss in mice.
- Osteogenic potential was enhanced in FoxO1-deficient osteoblasts.
- FoxO1 deficiency enhanced NLRP3 inflammasome signaling under oxidative stress.
Conclusions:
- FoxO1 plays a detrimental role in age-related alveolar bone resorption.
- Targeting FoxO1 may offer a novel therapeutic strategy for periodontitis.
- The NLRP3 inflammasome pathway is implicated in FoxO1-mediated bone loss.
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