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Updated: Jul 30, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
AI-Based Gut-Brain Axis Digital Twins
Stéphane Meystre1, Ruud van Stiphout1, Annelies Goris1
1Imec within OnePlanet Research Center, Nijmegen & Wageningen, The Netherlands.
Abstract:
More than 40% of the adult population suffers from functional gastrointestinal disorders, now considered disorders of the "gut-brain axis" (GBA) interactions, a very complex bidirectional neural, endocrine, immune, and humoral communication system modulated by the microbiota. To help discover, understand, and manage GBA disorders, the OnePlanet research center is developing digital twins focused on the GBA, combining novel sensors with artificial intelligence algorithms, providing descriptive, diagnostic, predictive or prescriptive feed-back.
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