Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

336
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
336
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

120
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
120
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

60.7K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.7K
Neural Regulation01:37

Neural Regulation

39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethical Implications of Small Language Models (SLMs) in Healthcare Applications.

Studies in health technology and informatics·2026
Same author

Towards a ModernBERT Model Adapted to the Biomedical Domain in Italian.

Studies in health technology and informatics·2026
Same author

Urinary Proteomics as a Noninvasive Readout of Obesity-associated Inflammation.

Journal of the Endocrine Society·2026
Same author

Mealtime Physiological Responses in Individuals With Eating Disorders and Healthy Controls.

European eating disorders review : the journal of the Eating Disorders Association·2025
Same author

Large language models for biomedicine: foundations, opportunities, challenges, and best practices.

Journal of the American Medical Informatics Association : JAMIA·2024
Same author

High Accuracy Open-Source Clinical Data De-Identification: The CliniDeID Solution.

Studies in health technology and informatics·2024
Same journal

The Essential Components and Critical Conditions for Success in a Learning Health System in Oncology.

Studies in health technology and informatics·2026
Same journal

Use of Artificial Intelligence in Screening for Adolescent Idiopathic Scoliosis: A Scoping Review.

Studies in health technology and informatics·2026
Same journal

Movement Related Biomechanics in Adolescent Idiopathic Scoliosis: A Review of Reviews.

Studies in health technology and informatics·2026
Same journal

The Impact of Surgical Correction of Adolescent Idiopathic Scoliosis Using Posterior Spinal Fusion on Selected Radiological Parameters and Respiratory Function.

Studies in health technology and informatics·2026
Same journal

Acute Effect of Physio-logic® Exercises on Muscle Tone and Stiffness in Adolescent Idiopathic Scoliosis Patients: A Preliminary Study.

Studies in health technology and informatics·2026
Same journal

Effects of Integrated Music and Occupational Therapy on Motor and Autonomic Function in Children with Neurogenic Scoliosis.

Studies in health technology and informatics·2026
See all related articles

Related Experiment Video

Updated: Jul 30, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.7K

AI-Based Gut-Brain Axis Digital Twins.

Stéphane Meystre1, Ruud van Stiphout1, Annelies Goris1

  • 1Imec within OnePlanet Research Center, Nijmegen & Wageningen, The Netherlands.

Studies in Health Technology and Informatics
|May 19, 2023
PubMed
Summary
This summary is machine-generated.

Functional gastrointestinal disorders affect over 40% of adults. Researchers are creating digital twins of the gut-brain axis (GBA) using sensors and AI to better understand and manage these complex conditions.

Keywords:
Artificial IntelligenceDigital TwinGut-Brain AxisSmart sensors

More Related Videos

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

699
Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
09:13

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

511

Related Experiment Videos

Last Updated: Jul 30, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

2.7K
Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
07:29

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation

Published on: December 29, 2023

699
Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut
09:13

Two-dimensional Porcine Intestinal Organoids Reflecting the Physiological Properties of Native Gut

Published on: January 31, 2025

511

Area of Science:

  • Gastroenterology and Neuroscience
  • Computational Biology and Artificial Intelligence

Background:

  • Functional gastrointestinal disorders (FGIDs) impact over 40% of adults.
  • FGIDs are increasingly understood as disorders of the gut-brain axis (GBA) interactions.
  • The GBA involves complex bidirectional communication via neural, endocrine, immune, and humoral pathways, modulated by the gut microbiota.

Purpose of the Study:

  • To develop novel digital twin technology for the gut-brain axis (GBA).
  • To facilitate the discovery, understanding, and management of GBA disorders.
  • To integrate advanced sensing technologies with artificial intelligence for GBA research.

Main Methods:

  • Development of specialized digital twins focused on the GBA.
  • Integration of novel sensor technologies for data acquisition.
  • Application of artificial intelligence algorithms for data analysis and feedback generation.

Main Results:

  • Creation of a digital twin platform for GBA research.
  • Capability for descriptive, diagnostic, predictive, and prescriptive feedback.
  • Potential for improved understanding and management of FGIDs.

Conclusions:

  • Digital twin technology offers a promising approach to studying the complex GBA.
  • AI and novel sensors are key components in developing these advanced research tools.
  • This approach has the potential to significantly advance the field of GBA disorder management.