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Experimental Approaches to Tissue Engineering
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Horizon Scanning in Tissue Engineering Using Citation Network Analysis.

Kouhei Otsuka1, Takuya Takata1, Hajime Sasaki2

  • 1Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.

Therapeutic Innovation & Regulatory Science
|May 19, 2023
PubMed
Summary
This summary is machine-generated.

Bibliographic citation network analysis can aid horizon scanning in interdisciplinary fields like tissue engineering. However, tracking technology evolution and clinical applications requires careful identification of basic technologies and their integration.

Keywords:
3D bio-printingBibliometricCitation network analysisHorizon scanningRegulatory scienceScaffoldText miningTissue engineering

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Area of Science:

  • Biotechnology
  • Medical Informatics
  • Materials Science

Background:

  • Horizon scanning is crucial for identifying emerging technologies needing new regulations.
  • Bibliographic citation network analysis offers a novel approach to horizon scanning.

Purpose of the Study:

  • To investigate the application of bibliographic citation network analysis for horizon scanning.
  • To assess the method's utility in interdisciplinary fields, focusing on tissue engineering and 3D bio-printing.

Main Methods:

  • Analyzed 233,968 articles on tissue engineering, regenerative medicine, biofabrication, and additive manufacturing (1900-2021).
  • Examined citation networks to track the evolution of 3D bio-printing.
  • Investigated research trends (2019-2021) in tissue engineering, including microfluidics, scaffolds, electrospinning, and conductive polymers.

Main Results:

  • Citation network analysis confirmed the evolution of 3D bio-printing.
  • Key articles on clinical applications of 3D bio-printed products were found in separate clusters from 3D bio-printer articles.
  • Identified microfluidics, electrospinning, and conductive polymers as key technologies in tissue engineering.

Conclusions:

  • Bibliographic citation network analysis is applicable to horizon scanning in interdisciplinary fields.
  • Critical factors for success include identifying basic technologies and tracking research progress and integration.