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Related Experiment Video

Updated: Jul 29, 2025

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Preparing Surrogate Abnormal Quality Control Samples for Platelet Function Studies and Viscoelastic Testing.

Robert C Gosselin¹

¹Thrombosis & Hemostasis Center, University of California, Davis Health System, Sacramento, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|May 19, 2023

Summary

This summary is machine-generated.

Clinical laboratories can prepare samples for quality control (QC) testing when commercial controls are unavailable. This guidance addresses challenges in QC for platelet function and viscoelastic measurements.

Keywords:

Agonists Aspirin Heparin P2Y12 inhibitor Plasminogen activator Platelet aggregation Platelet function Platelet glycoprotein receptor IIb-IIIa inhibitor Viscoelastic test

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Area of Science:

Clinical Laboratory Science
Hematology
Diagnostic Testing

Background:

Current US regulations (Clinical and Laboratory Improvement Act - CLIA) mandate specific quality control (QC) procedures for clinical laboratories.
Standard QC protocols may be insufficient for certain tests, including coagulation, platelet function, and viscoelastic measurements, due to sample type, lack of commercial controls, or rare samples.

Purpose of the Study:

To provide provisional guidance for preparing laboratory-generated samples for quality control.
To ensure reliable verification of reagent and testing performance for specific assays.

Main Methods:

Guidance focuses on preparing samples to serve as quality control materials.
Addresses challenges related to whole blood samples, lack of commercial controls, and unusual sample types.

Main Results:

Provisional guidance is offered for creating QC samples.
Aims to bridge gaps where standard QC materials are inadequate.

Conclusions:

Laboratory-developed QC samples can supplement or replace commercial controls when necessary.
This approach supports accurate testing for platelet function and viscoelastic measurements.