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Measurement of Blood Viscoelasticity Using Thromboelastography.

Oksana Volod1, Alice Runge2

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Methods in Molecular Biology (Clifton, N.J.)
|May 19, 2023
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Summary

Thromboelastography (TEG), a viscoelastic test (VET), evaluates blood clotting. Newer TEG 6s offers improved performance over older TEG 5000, aiding hemostasis assessment in critical care.

Keywords:
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Area of Science:

  • Hemostasis and Thrombosis
  • Medical Diagnostics
  • Biomedical Engineering

Background:

  • Thromboelastography (TEG) was the first viscoelastic test (VET), developed in 1948 to assess whole blood hemostatic competence.
  • VETs, including TEG, are crucial for evaluating hemostasis in complex medical scenarios like cardiac surgery, liver transplantation, and trauma.
  • The evolution of hemostasis models, particularly the cell-based model in 1994, highlighted the significance of platelets and tissue factor, increasing TEG's utility.

Purpose of the Study:

  • To review the historical development and evolution of Thromboelastography (TEG).
  • To compare the advantages and limitations of the traditional TEG 5000 and the newer TEG 6s systems.
  • To discuss factors influencing TEG interpretation and their clinical relevance.

Main Methods:

  • Review of historical data and development of Thromboelastography (TEG).
  • Comparative analysis of TEG 5000 (cup and pin technology) and TEG 6s (resonance technology, cartridge-based).
  • Discussion of factors affecting TEG tracings and interpretation.

Main Results:

  • TEG 5000 utilizes the original cup and pin technology.
  • TEG 6s represents a new generation employing resonance technology for improved performance and precision.
  • Understanding factors affecting TEG is critical for accurate interpretation.

Conclusions:

  • Viscoelastic testing (VET) has become indispensable in managing hemostasis in critical care settings.
  • The newer TEG 6s system offers advancements in automated blood viscoelastic property assessment.
  • Careful consideration of influencing factors is essential for reliable TEG analysis.