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Related Concept Videos

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Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Related Experiment Video

Updated: Jul 29, 2025

Analysis of Craniomaxillofacial Malformations in Mice Using Three-dimensional Microcomputed Tomography
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Spatial analysis of transnasal olfactory cleft access: a computed tomography study.

Teffran Joey Chan1,2, Melissa Lee2, Andrew Vernu Thamboo1

  • 1Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of British Columbia, St. Paul Sinus Center, Vancouver, BC, Canada.

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale
|May 19, 2023
PubMed
Summary

This study quantifies nasal anatomy for improved drug delivery. Narrower devices than 3.2 mm may enhance topical medication access to the olfactory cleft.

Keywords:
computed tomography studyintranasal drug applicationolfactory clefttrans cribriform

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Area of Science:

  • Anatomy
  • Medical Imaging
  • Drug Delivery

Background:

  • The spatial relationship between the naris and olfactory cleft is not well-quantified.
  • Accurate anatomical measurements are crucial for optimizing topical medication delivery and device design.

Purpose of the Study:

  • To quantify the spatial access from the naris to the olfactory cleft.
  • To analyze the relationship between the middle turbinate, septum, anterior nasal spine, and cribriform plate.
  • To inform the design of improved topical drug applicators.

Main Methods:

  • Analysis of 100 CT scans from adult patients without sinonasal pathology or prior surgery.
  • Bilateral measurements of bony landmarks by two blinded authors.
  • Inter-rater reliability assessed using intraclass correlation.

Main Results:

  • Average distance from anterior nasal spine to olfactory cleft: 52.3 mm.
  • Average cribriform plate length: 18.8 mm.
  • Average olfactory cleft width at anterior and posterior cribriform plate edges: 2.3 mm and 2.0 mm, respectively.

Conclusions:

  • A 52.3 mm distance from naris to cribriform plate anterior border was found.
  • An average path width of 3.2 mm suggests devices narrower than this could improve direct drug delivery.