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Related Experiment Video

Updated: Jul 29, 2025

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

Dynamic brain states in spatial neglect after stroke.

Sara Spadone¹, Francesco de Pasquale², Anna Digiovanni¹

¹Department of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.

Frontiers in Systems Neuroscience

|May 19, 2023

Summary

This summary is machine-generated.

Spatial neglect after stroke is linked to altered brain states, with affected individuals spending more time in less organized brain network configurations. These dynamic changes in brain connectivity offer insights into spatial attention deficits and potential treatments.

Keywords:

brain states cluster analysis dynamic functional connectivity modularity neglect

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Area of Science:

Neuroscience
Cognitive Neurology
Brain Connectivity

Background:

Previous research links spatial neglect to altered functional connectivity and brain system topology.
The temporal dynamics of these network alterations in spatial neglect remain largely unexplored.

Purpose of the Study:

To investigate the association between dynamic brain states and spatial neglect following focal brain lesions.
To explore how temporal fluctuations in functional brain networks relate to the severity of spatial neglect.

Main Methods:

Resting-state functional MRI was used to assess dynamic functional connectivity in 20 right-hemisphere stroke patients within two weeks of stroke onset.
Sliding window analysis and network clustering identified seven resting-state networks and distinct brain states.
Neuropsychological assessments evaluated neglect severity, correlating it with time spent in different brain states.

Main Results:

Two distinct brain states were identified: one less modular and segregated (associated with neglect) and one more modular and segregated (associated with non-neglect).
Patients with spatial neglect spent more time in the less modular state, characterized by weaker intra-network coupling and sparser inter-network interactions.
A state with blurred network distinctions and low modularity was unique to the neglect group, while a highly segregated state was unique to the non-neglect group.

Conclusions:

Stroke-induced spatial attention deficits are associated with significant alterations in the time-varying properties of large-scale brain network interactions.
Dynamic changes in brain network organization, particularly reduced modularity and segregation, are crucial in the pathophysiology of spatial neglect.
Findings suggest potential therapeutic targets by modulating these dynamic brain states to improve spatial attention deficits.