Related Experiment Video
Updated: Jul 29, 2025
10:42
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
17.2K
Host-Microbiome Associations in Saliva Predict COVID-19 Severity
Hend Alqedari1,2, Khaled Altabtbaei3, Josh L Espinoza4
1Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, 02115, USA; Dasman Diabetes Institute, Kuwait.
Biorxiv : the Preprint Server for Biology
|May 19, 2023
Summary
The oral microbiome and salivary cytokines may predict COVID-19 severity. Alterations in the oral microbiome and immune responses are linked to disease progression in patients with Severe Acute Respiratory Syndrome Coronavirus 2.
Area of Science:
- Microbiology
- Immunology
- Virology
Background:
- The oral microbiota's role in viral infections is established, but its specific involvement in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogenesis remains unclear.
- Coordinated microbiome and inflammatory responses in mucosal and systemic compartments during SARS-CoV-2 infection require further investigation.
Conclusions:
- Oral microbiome and salivary cytokines show potential as predictive biomarkers for COVID-19 status and severity.
- Findings suggest local mucosal immune suppression and systemic hyperinflammation contribute to COVID-19 pathogenesis in immunologically naive populations.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
12.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.1K
01:50What is Monogastric Digestion?
71.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.7K