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Updated: Jul 29, 2025

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
Published on: August 16, 2012
Powell lens-based line-field spectral domain optical coherence tomography system for cellular resolution imaging of
Keyu Chen1, Weixiang Song1, Le Han1
1Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Abstract:
A Powell lens is used in a line-field spectral domain OCT (PL-LF-SD-OCT) system to generate a line-shaped imaging beam with almost uniform distribution of the optical power in the line direction. This design overcomes the severe sensitivity loss (∼10 dB) observed along the line length direction (B-scan) in LF-OCT systems based on cylindrical lens line generators. The PL-LF-SD-OCT system offers almost isotropic spatial resolution (Δx and Δy ∼2 µm, Δz ∼1.8 µm) in free space and sensitivity of ∼87 dB for 2.5 mW imaging power at 2,000 fps imaging rate with only ∼1.6 dB sensitivity loss along the line length. Images acquired with the PL-LF-SD-OCT system allow for visualization of the cellular and sub-cellular structure of biological tissues.
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